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Encyclopedia of Signaling Molecules pp 3351–3355Cite as

Natriuretic Peptide Receptor Type B (NPRB)

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Synonyms

AMDM; ANPb; ANPRB; ECDM; GCB; GC-B; GUC2B; GUCY2B; NPR2 (natriuretic peptide receptor 2); NPRB; NPRBi; SNSK

Historical Background

The natriuretic peptides (NP) system is a family of peptides named A, B, and C-type natriuretic peptides (ANP, BNP, CNP) and urodilatin (URO), synthetized by the heart (ANP and BNP), kidney (URO), and vascular smooth muscle (CNP) but also by other cells widely dispersed in different organs and tissues (Koller and Goeddel 1992). The NP family plays an essential role on the regulation of blood pressure, the intravascular volume, and electrolyte homeostasis in mammals. Based on the fact that their main actions are exerted on regulation of the cardiovascular system, the NP are included within the big family of vasoactive peptides, together with angiotensin II, endothelins, bradikinin, and vasopressin among others (Padney 2015).

Binding of NP to either natriuretic peptide receptor type A (NPRA) or type B (NPRB) leads to activation of particulate...

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Natriuretic Peptide Receptor Type B (NPRB), Fig. 1
Natriuretic Peptide Receptor Type B (NPRB), Fig. 2

References

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Authors and Affiliations

  1. Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Cátedra de Anatomía e Histología, Buenos Aires, Argentina

    Silvana M. Cantú, Adriana S. Donoso & Ana M. Puyó

  2. Instituto de Investigaciones Cardiológicas “Prof. Dr. Alberto C. Taquini”, ININCA, UBA-CONICET, Buenos Aires, Argentina

    María I. Rosón & Marcelo R. Choi

  3. Cátedra de Anatomía e Histología, Departamento de Ciencias Biológicas, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina

    Marcelo R. Choi

Authors
  1. Silvana M. Cantú
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  2. María I. Rosón
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  3. Adriana S. Donoso
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  4. Ana M. Puyó
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  5. Marcelo R. Choi
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Corresponding author

Correspondence to Silvana M. Cantú .

Editor information

Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Cantú, S.M., Rosón, M.I., Donoso, A.S., Puyó, A.M., Choi, M.R. (2018). Natriuretic Peptide Receptor Type B (NPRB). In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101994

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