Historical Background
The natriuretic peptides (NP) system is a family of peptides named A, B, and C-type natriuretic peptides (ANP, BNP, CNP) and urodilatin (URO), synthetized by the heart (ANP and BNP), kidney (URO), and vascular smooth muscle (CNP) but also by other cells widely dispersed in different organs and tissues (Koller and Goeddel 1992). The NP family plays an essential role on the regulation of blood pressure, the intravascular volume, and electrolyte homeostasis in mammals. Based on the fact that their main actions are exerted on regulation of the cardiovascular system, the NP are included within the big family of vasoactive peptides, together with angiotensin II, endothelins, bradikinin, and vasopressin among others (Padney 2015).
Binding of NP to either natriuretic peptide receptor type A (NPRA) or type B (NPRB) leads to activation of particulate...
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Cantú SM, Donoso AS, Kouyoumdzian NM, Rukavina Mikusic NL, Puyó AM, et al. Clinical aspects of C-Type natriuretic peptide on the cardiovascular system. Int J Clin Endocrinol Metab. 2015;1(2):31–6.
Garbers DL. Guanylyl cyclase receptors and their endocrine, paracrine, and autocrine ligands. Cell. 1992;71(1):1–4.
Garbers DL, Chrisman TD, Wiegn P, Katafuchi T, Albanesi JP, Bielinski V, et al. Membrane guanylyl cyclase receptors: an update. Trends Endocrinol Metab. 2006;17(6):251–8.
Khurana ML, Pandey KN. Receptor-mediated stimulatory effect of atrial natriuretic factor, brain natriuretic peptide, and C-type natriuretic peptide on testosterone production in purified mouse Leydig cells: activation of cholesterol side-chain cleavage enzyme. Endocrinology. 1993;133(5):2141–9.
Koller KJ, Goeddel DV. Molecular biology of the natriuretic peptides and their receptors. Circulation. 1992;86(4):1081–8.
Pandey KN, Singh S. Molecular cloning and expression of murine guanylate cyclase/atrial natriuretic factor receptor cDNA. J Biol Chem. 1990;265(21):12342–8.
Padney KN. Endocytosis and trafficking of natriuretic peptide receptor-A: potential role of short sequence motif. Membranes. 2015;5:253–87.
Potter LR. Guanylyl cyclase structure, function and regulation. Cell Signal. 2011;23(12):1921–6.
Rahmutula D, Nakayama T, Soma M, Sato M, Izumi Y, et al. Systematic screening of type B human natriuretic peptide receptor gene polymorphisms and association with essential hypertension. J Hum Hypertens. 2001;15(7):471–4.
Rehemudula D, Nakayama T, Soma M, Takahashi Y, Uwabo J, Sato M, et al. Structure of the type B human natriuretic peptide receptor gene and association of a novel microsatellitepolymorphism with essential hypertension. Circ Res. 1999;84(5):605–10.
Schlueter N, de Sterke A, Willmes DM, Spranger J, Jordan J, et al. Metabolic actions of natriuretic peptides and therapeutic potential in the metabolic syndrome. Pharmacol Ther. 2014;144:12–27.
Vasques GA, Arnhold IJ, Jorge AA. Role of the natriuretic peptide system in normal growth and growth disorders. Horm Res Paediatr. 2014;82(4):222–9.
Wang SR. Heterozygous mutations in natriuretic peptide receptor-B (NPR2) gene as a cause of short stature. Hum Mutat. 2015;36(4):474–81.
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Cantú, S.M., Rosón, M.I., Donoso, A.S., Puyó, A.M., Choi, M.R. (2018). Natriuretic Peptide Receptor Type B (NPRB). In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101994
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DOI: https://doi.org/10.1007/978-3-319-67199-4_101994
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