Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Natriuretic Peptide Receptor Type B (NPRB)

  • Silvana M. CantúEmail author
  • María I. Rosón
  • Adriana S. Donoso
  • Ana M. Puyó
  • Marcelo R. Choi
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101994


Historical Background

The natriuretic peptides (NP) system is a family of peptides named A, B, and C-type natriuretic peptides (ANP, BNP, CNP) and urodilatin (URO), synthetized by the heart (ANP and BNP), kidney (URO), and vascular smooth muscle (CNP) but also by other cells widely dispersed in different organs and tissues (Koller and Goeddel 1992). The NP family plays an essential role on the regulation of blood pressure, the intravascular volume, and electrolyte homeostasis in mammals. Based on the fact that their main actions are exerted on regulation of the cardiovascular system, the NP are included within the big family of vasoactive peptides, together with angiotensin II, endothelins, bradikinin, and vasopressin among others (Padney 2015).

Binding of NP to either natriuretic peptide receptor type A (NPRA) or type B (NPRB) leads to activation of...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Silvana M. Cantú
    • 1
    Email author
  • María I. Rosón
    • 2
  • Adriana S. Donoso
    • 1
  • Ana M. Puyó
    • 1
  • Marcelo R. Choi
    • 2
    • 3
  1. 1.Universidad de Buenos Aires, Facultad de Farmacia y BioquímicaCátedra de Anatomía e HistologíaBuenos AiresArgentina
  2. 2.Instituto de Investigaciones Cardiológicas “Prof. Dr. Alberto C. Taquini”, ININCA, UBA-CONICETBuenos AiresArgentina
  3. 3.Cátedra de Anatomía e Histología, Departamento de Ciencias Biológicas, Facultad de Farmacia y Bioquímica, Universidad de Buenos AiresBuenos AiresArgentina