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Encyclopedia of Signaling Molecules pp 2549–2557Cite as

IL-4 and IL-13 Receptors

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Synonyms

IL-13Rα: CD213a1; CT19; IL-13 receptor alpha 1; IL-13R; IL-13R alpha 1; IL-13RA1; Interleukin 12 receptor alpha 1; NR4

IL-13Rα2: CD213a2; IL-13 receptor alpha 2; IL-13BP; IL-13R alpha 2; IL-13Ra2; Il13rA2; Il13ra2; IL-13Ralpha2; Interleukin 13 receptor alpha 2

IL-4Rα: CD124; IL-4 receptor alpha; IL-4RA; Interleukin 4 receptor, alpha

Historical Background

The IL-4 and IL-13 receptor subunits were among the first cytokine receptor systems described in the 1980s enabling the discovery of cytokine cell signaling, receptor subunit formation and cytokine regulation of immune responses. The IL-4R complex has been shown to be central in regulating type II-mediated immunity and inflammation toward extracellular parasitic infections, regulation of B-cell antibody isotype class switching and affinity maturation, and the progression of allergy, asthma, and atopic dermatitis in susceptible individuals. Many studies over the last 20 years have revealed the role of IL-4/IL-13R in the...

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Authors and Affiliations

  1. Molecular Mucosal Vaccine Immunology Group, Department of Immunology and infectious Disease, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT, 2601, Australia

    Charani Ranasinghe, Sreeja Roy, Zheyi Li, Mayank Khanna & Ronald J. Jackson

Authors
  1. Charani Ranasinghe
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  2. Sreeja Roy
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  3. Zheyi Li
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  4. Mayank Khanna
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  5. Ronald J. Jackson
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Corresponding author

Correspondence to Charani Ranasinghe .

Editor information

Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Ranasinghe, C., Roy, S., Li, Z., Khanna, M., Jackson, R.J. (2018). IL-4 and IL-13 Receptors. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101978

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