Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

IL-4 and IL-13 Receptors

  • Charani RanasingheEmail author
  • Sreeja Roy
  • Zheyi Li
  • Mayank Khanna
  • Ronald J. Jackson
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101978


Historical Background

The IL-4 and IL-13 receptor subunits were among the first cytokine receptor systems described in the 1980s enabling the discovery of cytokine cell signaling, receptor subunit formation and cytokine regulation of immune responses. The IL-4R complex has been shown to be central in regulating type II-mediated immunity and inflammation toward extracellular parasitic infections, regulation of B-cell antibody isotype class switching and affinity maturation, and the progression of allergy, asthma, and atopic dermatitis in susceptible individuals. Many studies over the last 20 years have revealed the role of...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Charani Ranasinghe
    • 1
    Email author
  • Sreeja Roy
    • 1
  • Zheyi Li
    • 1
  • Mayank Khanna
    • 1
  • Ronald J. Jackson
    • 1
  1. 1.Molecular Mucosal Vaccine Immunology Group, Department of Immunology and infectious Disease, The John Curtin School of Medical ResearchThe Australian National UniversityCanberraAustralia