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Encyclopedia of Signaling Molecules pp 267–280Cite as

AKT

  • Reference work entry
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Synonyms

CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA

Historical Background

AKT is a serine/threonine kinase member of the AGC family of protein kinases, which is conserved from primitive metazoan to humans, and it was discovered in 1977 (Staal et al. 1977). There are three isoforms of AKT in mammals (AKT1, AKT2, and AKT3), each transcribed from separate genes (Jones et al. 1991a, b; Konishi et al. 1995; Brodbeck et al. 1999). During the last decade of the twentieth century, different groups contributed to establish that all AKT isoforms contain an N-terminal pleckstrin homology (PH) domain that interacts with phosphatidylinositol (3,4,5)-trisphosphate (PIP3) (Andjelkovic et al. 1997; Franke et al. 1997), a central kinase or catalytic domain and a C-terminal domain that contains an hydrophobic motif (HM) with homology to other AGC kinases (Alessi et al. 1996). It is now known that AKT exert their action by phosphorylating a wide variety of downstream targets containing the consensus...

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Authors and Affiliations

  1. Departamento de Fisiología y Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina

    Matías Blaustein

  2. CONICET-Universidad de Buenos Aires, Instituto de Fisiología, Biología Molecular y Neurociencias (IFIBYNE), Intendente Güiraldes 2160, C1428EHA, Buenos Aires, Argentina

    Matías Blaustein

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  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Blaustein, M. (2018). AKT. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101974

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