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Encyclopedia of Signaling Molecules pp 2520–2529Cite as

IKK (IκB Kinase) Complex

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Synonyms

IKKα: IκB Kinase α; IKK1; IκB Kinase 1; CHUK; Conserved Helix-loop-helix Ubiquitous Kinase

IKKβ: IκB Kinase β; IKK2; IκB Kinase 2

NEMO: NF-κB Essential MOdulator; IKKγ; IκB Kinase γ; IKKAP1; IκB Kinase Associated Protein 1; FIP3; 14.7K Interacting Protein 3

Historical Background

IKK (IκB kinase) is the central regulator of the NF-κB signaling pathway, which plays a key role in immunity, inflammation, and cell survival (Karin and Ben-Neriah 2000; Hayden and Ghosh 2012). NF-κB is the generic name of a family of inducible dimeric transcription factors that are sequestered in the cytoplasm of resting cells by interaction with inhibitory protein IκBs. Upon cell stimulation ΙκBs are phosphorylated, and this modification triggers their ubiquitination and destruction by the proteasome. This allows free NF-κB proteins to translocate in the nucleus and to activate their target genes (Fig. 1).

IKK (IκB Kinase) Complex, Fig. 1
figure 107 figure 107

The canonical pathway of NF-κB activation. Upon activation by...

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Acknowledgment

I thank Dr. Jérémie Gautheron for preparing Fig. 5.

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Authors and Affiliations

  1. INSERM U1038/BGE/BIG, CEA Grenoble, Grenoble, France

    Gilles Courtois

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  1. Gilles Courtois
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Correspondence to Gilles Courtois .

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Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Courtois, G. (2018). IKK (IκB Kinase) Complex. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101969

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