ADP-Ribosylation Factor-6 (ARF6)

Tamaddon-Jahromi, Salman; Kanamarlapudi, Venkateswarlu

doi:10.1007/978-3-319-67199-4_101965

ADP-Ribosylation Factor-6 (ARF6)

Salman Tamaddon-Jahromi² &
Venkateswarlu Kanamarlapudi²

Reference work entry
First Online: 01 January 2018

196 Accesses

Synonyms

Adenosine diphosphate-ribosylation factor-6; ADP-ribosylation factor-6; ARF6; Arf6

Historical Background

The first member of the ADP-ribosylation factor (ARF) family (ARF1) was originally discovered in 1984 as a cofactor for cholera toxin-mediated ADP-ribosylation of the heterotrimeric G-protein Gs (Kahn and Gilman 1984). Since then it has been found to be a Ras-related small GTPase with molecular weight of ~21 kDa (Sewell and Kahn 1988). Use of Saccharomyces cerevisiae as a model system allowed the determination of a role for ARF1 in the secretory pathway, along with its intracellular localization at the Golgi (Stearns et al. 1990). ARFs are ubiquitously expressed in eukaryotic cells and are major regulators of intercellular vesicle trafficking. They have been found to be conserved across many species, including yeast, fish, insects, and animals, indicating an important role for them in cellular functions. Subsequent characterization of the ARF family in mammals has...

This is a preview of subscription content, log in via an institution.

Chapter: USD 29.95; Price excludes VAT (USA)

eBook: USD 4,499.99; Price excludes VAT (USA)

Hardcover Book: USD 4,499.99; Price excludes VAT (USA)

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

Akiyama M, Zhou M, Sugimoto R, Hongu T, Furuya M, Funakoshi Y, et al. Tissue- and development-dependent expression of the small GTPase Arf6 in mice. Dev Dyn. 2010;239:3416–35. https://doi.org/10.1002/dvdy.22481.
Article PubMed CAS Google Scholar
Begle A, Tryoen-Toth P, de Barry J, Bader MF, Vitale N. ARF6 regulates the synthesis of fusogenic lipids for calcium-regulated exocytosis in neuroendocrine cells. J Biol Chem. 2009;284:4836–45. https://doi.org/10.1074/jbc.M806894200.
Article PubMed CAS Google Scholar
Caumont AS, Galas MC, Vitale N, Aunis D, Bader MF. Regulated exocytosis in chromaffin cells. Translocation of ARF6 stimulates a plasma membrane-associated phospholipase D. J Biol Chem. 1998;273:1373–9.
Article PubMed CAS Google Scholar
Cavenagh MM, Whitney JA, Carroll K, Zhang C, Boman AL, Rosenwald AG, et al. Intracellular distribution of Arf proteins in mammalian cells. Arf6 is uniquely localized to the plasma membrane. J Biol Chem. 1996;271:21767–74.
Article PubMed CAS Google Scholar
Chen B, Brinkmann K, Chen Z, Pak CW, Liao Y, Shi S, et al. The WAVE regulatory complex links diverse receptors to the actin cytoskeleton. Cell. 2014;156:195–207. https://doi.org/10.1016/j.cell.2013.11.048.
Article PubMed PubMed Central CAS Google Scholar
Choi W, Karim ZA, Whiteheart SW. Arf6 plays an early role in platelet activation by collagen and convulxin. Blood. 2006;107:3145–52. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16352809.
Article PubMed PubMed Central CAS Google Scholar
Claing A, Chen W, Miller WE, Vitale N, Moss J, Premont RT, et al. beta-Arrestin-mediated ADP-ribosylation factor 6 activation and beta 2-adrenergic receptor endocytosis. J Biol Chem. 2001;276:42509–13. https://doi.org/10.1074/jbc.M108399200.
Article PubMed CAS Google Scholar
D’Souza-Schorey C, Chavrier P. ARF proteins: roles in membrane traffic and beyond. Nat Rev Mol Cell Biol. 2006;7:347–58. https://doi.org/10.1038/nrm1910.
Article PubMed CAS Google Scholar
D’Souza-Schorey C, Stahl PD. Myristoylation is required for the intracellular localization and endocytic function of ARF6. Exp Cell Res. 1995;221:153–9. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7589240.
Article PubMed CAS Google Scholar
D’Souza-Schorey C, Boshans RL, McDonough M, Stahl PD, Van Aelst L. A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements. EMBO J. 1997;16:5445–54. https://doi.org/10.1093/emboj/16.17.5445.
Article PubMed PubMed Central Google Scholar
D’Souza-Schorey C, van Donselaar E, Hsu VW, Yang C, Stahl PD, Peters PJ. ARF6 targets recycling vesicles to the plasma membrane: insights from an ultrastructural investigation. J Cell Biol. 1998;140:603–16. https://doi.org/10.1083/jcb.140.3.603.
Article PubMed PubMed Central Google Scholar
Davies JC, Bain SC, Kanamarlapudi V. ADP-ribosylation factor 6 regulates endothelin-1-induced lipolysis in adipocytes. Biochem Pharmacol. 2014a;90:406–13. https://doi.org/10.1016/j.bcp.2014.06.012.
Article PubMed CAS Google Scholar
Davies JC, Tamaddon-Jahromi S, Jannoo R, Kanamarlapudi V. Cytohesin 2/ARF6 regulates preadipocyte migration through the activation of ERK1/2. Biochem Pharmacol. 2014b;92:651–60. https://doi.org/10.1016/j.bcp.2014.09.023.
Article PubMed CAS Google Scholar
Di Paolo G, De Camilli P. Phosphoinositides in cell regulation and membrane dynamics. Nature. 2006;443:651–7. https://doi.org/10.1038/nature05185.
Article PubMed CAS Google Scholar
Eva R, Crisp S, Marland JR, Norman JC, Kanamarlapudi V, ffrench-Constant C, et al. ARF6 directs axon transport and traffic of integrins and regulates axon growth in adult DRG neurons. J Neurosci. 2012;32:10352–64. https://doi.org/10.1523/jneurosci.1409-12.2012.
Article PubMed PubMed Central CAS Google Scholar
Fielding AB, Schonteich E, Matheson J, Wilson G, Yu X, Hickson GRX, et al. Rab11-FIP3 and FIP4 interact with Arf6 and the Exocyst to control membrane traffic in cytokinesis. EMBO J. 2005;24:3389–99. https://doi.org/10.1038/sj.emboj.7600803.
Article PubMed PubMed Central CAS Google Scholar
Galas MC, Helms JB, Vitale N, Thierse D, Aunis D, Bader MF. Regulated exocytosis in chromaffin cells. A potential role for a secretory granule-associated ARF6 protein. J Biol Chem. 1997;272:2788–93.
Article PubMed CAS Google Scholar
Gaschet J, Hsu VW. Distribution of ARF6 between membrane and cytosol is regulated by its GTPase cycle. J Biol Chem. 1999;274:20040–5. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10391955.
Article CAS Google Scholar
George AA, Hayden S, Stanton GR, Brockerhoff SE. Arf6 and the 5’phosphatase of Synaptojanin 1 regulate autophagy in cone photoreceptors. Inside Cell. 2016;1:117–33. https://doi.org/10.1002/icl3.1044.
Article PubMed PubMed Central Google Scholar
Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144:646–74. https://doi.org/10.1016/j.cell.2011.02.013.
Article PubMed CAS Google Scholar
Hashimoto A, Oikawa T, Hashimoto S, Sugino H, Yoshikawa A, Otsuka Y, et al. P53- and mevalonate pathway-driven malignancies require Arf6 for metastasis and drug resistance. J Cell Biol. 2016a;213:81–95. https://doi.org/10.1083/jcb.201510002.
Article PubMed PubMed Central CAS Google Scholar
Hashimoto S, Mikami S, Sugino H, Yoshikawa A, Hashimoto A, Onodera Y, et al. Lysophosphatidic acid activates Arf6 to promote the mesenchymal malignancy of renal cancer. Nat Commun. 2016b;7:10656. https://doi.org/10.1038/ncomms10656.
Article PubMed PubMed Central CAS Google Scholar
Haun RS, Tsai SC, Adamik R, Moss J, Vaughan M. Effect of myristoylation on GTP-dependent binding of ADP-ribosylation factor to Golgi. J Biol Chem. 1993;268:7064–8. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8463239.
Hongu T, Yamauchi Y, Funakoshi Y, Katagiri N, Ohbayashi N, Kanaho Y. Pathological functions of the small GTPase Arf6 in cancer progression: tumor angiogenesis and metastasis. Small GTPases. 2016;7:47–53. https://doi.org/10.1080/21541248.2016.1154640.
Article PubMed PubMed Central CAS Google Scholar
Hosaka M, Toda K, Takatsu H, Torii S, Murakami K, Nakayama K. Structure and intracellular localization of mouse ADP-ribosylation factors type 1 to type 6 (ARF1-ARF6). J Biochem (Tokyo). 1996;120:813–9. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8947846.
Article PubMed CAS Google Scholar
Houndolo T, Boulay PL, Claing A. G protein-coupled receptor endocytosis in ADP-ribosylation factor 6-depleted cells. J Biol Chem. 2005;280:5598–604. https://doi.org/10.1074/jbc.M411456200.
Article PubMed CAS Google Scholar
Huang Y, Joshi S, Xiang B, Kanaho Y, Li Z, Bouchard BA, et al. Arf6 controls platelet spreading and clot retraction via integrin alphaIIbbeta3 trafficking. Blood. 2016;127:1459–67. https://doi.org/10.1182/blood-2015-05-648550.
Article PubMed PubMed Central CAS Google Scholar
Humphreys D, Davidson AC, Hume PJ, Makin LE, Koronakis V. Arf6 coordinates actin assembly through the WAVE complex, a mechanism usurped by Salmonella to invade host cells. Proc Natl Acad Sci USA. 2013;110:16880–5. https://doi.org/10.1073/pnas.1311680110.
Article PubMed PubMed Central CAS Google Scholar
Humphreys D, Singh V, Koronakis V. Inhibition of WAVE regulatory complex activation by a bacterial virulence effector counteracts pathogen phagocytosis. Cell Rep. 2016;17:697–707. https://doi.org/10.1016/j.celrep.2016.09.039.
Article PubMed PubMed Central CAS Google Scholar
Jang DJ, Jun YW, Shim J, Sim SE, Lee JA, Lim CS, et al. Activation of Aplysia ARF6 induces neurite outgrowth and is sequestered by the overexpression of the PH domain of Aplysia Sec7 proteins. Neurobiol Learn Mem. 2016;S1074-7427(16):30092–2. https://doi.org/10.1016/j.nlm.2016.06.017.
Kahn RA, Gilman AG. Purification of a protein cofactor required for ADP-ribosylation of the stimulatory regulatory component of adenylate cyclase by cholera toxin. J Biol Chem. 1984;259:6228–34.
PubMed CAS Google Scholar
Kahn RA, Goddard C, Newkirk M. Chemical and immunological characterization of the 21-kDa ADP-ribosylation factor of adenylate cyclase. J Biol Chem. 1988;263:8282–7.
PubMed CAS Google Scholar
Kanamarlapudi V, Owens SE, Saha K, Pope RJ, Mundell SJ. ARF6-dependent regulation of P2Y receptor traffic and function in human platelets. PLoS One. 2012a;7:e43532. https://doi.org/10.1371/journal.pone.0043532.
Article PubMed PubMed Central CAS Google Scholar
Kanamarlapudi V, Thompson A, Kelly E, Lopez Bernal A. ARF6 activated by the LHCG receptor through the cytohesin family of guanine nucleotide exchange factors mediates the receptor internalization and signaling. J Biol Chem. 2012b;287:20443–55. https://doi.org/10.1074/jbc.M112.362087.
Article PubMed PubMed Central CAS Google Scholar
Kim HS. Assignment of the human ADP-ribosylation factor 6 (ARF6) gene to chromosome 7q22.1 by radiation hybrid mapping. Cytogenet Cell Genet. 1999;84:94. https://doi.org/10.1159/000015225.
Article PubMed CAS Google Scholar
Koo TH, Eipper BA, Donaldson JG. Arf6 recruits the Rac GEF Kalirin to the plasma membrane facilitating Rac activation. BMC Cell Biol. 2007;8:29. https://doi.org/10.1186/1471-2121-8-29.
Article PubMed PubMed Central CAS Google Scholar
Krauss M, Kinuta M, Wenk MR, De Camilli P, Takei K, Haucke V. ARF6 stimulates clathrin/AP-2 recruitment to synaptic membranes by activating phosphatidylinositol phosphate kinase type Iγ. J Cell Biol. 2003;162:113–24. https://doi.org/10.1083/jcb.200301006.
Article PubMed PubMed Central CAS Google Scholar
Krcmery J, Camarata T, Kulisz A, Simon HG. Nucleocytoplasmic functions of the PDZ-LIM protein family: new insights into organ development. BioEssays. 2010;32:100–8. https://doi.org/10.1002/bies.200900148.
Article PubMed PubMed Central CAS Google Scholar
Lee FJ, Moss J, Vaughan M. Human and Giardia ADP-ribosylation factors (ARFs) complement ARF function in Saccharomyces cerevisiae. J Biol Chem. 1992;267:24441–5.
PubMed CAS Google Scholar
Macia E, Luton F, Partisani M, Cherfils J, Chardin P, Franco M. The GDP-bound form of Arf6 is located at the plasma membrane. J Cell Sci. 2004;117:2389–98. https://doi.org/10.1242/jcs.01090.
Article PubMed CAS Google Scholar
Marquer C, Tian H, Yi J, Bastien J, Dall’Armi C, Yang-Klingler Y, et al. Arf6 controls retromer traffic and intracellular cholesterol distribution via a phosphoinositide-based mechanism. Nat Commun. 2016;7:11919. https://doi.org/10.1038/ncomms11919.
Article PubMed PubMed Central CAS Google Scholar
Menetrey J, Macia E, Pasqualato S, Franco M, Cherfils J. Structure of Arf6-GDP suggests a basis for guanine nucleotide exchange factors specificity. Nat Struct Mol Biol. 2000;7:466–9.
Article CAS Google Scholar
Montagnac G, Sibarita JB, Loubery S, Daviet L, Romao M, Raposo G, et al. ARF6 Interacts with JIP4 to control a motor switch mechanism regulating endosome traffic in cytokinesis. Curr Biol. 2009;19:184–95. https://doi.org/10.1016/j.cub.2008.12.043.
Article PubMed CAS Google Scholar
Mossessova E, Gulbis JM, Goldberg J. Structure of the guanine nucleotide exchange factor Sec7 domain of human arno and analysis of the interaction with ARF GTPase. Cell. 1998;92:415–23.
Article PubMed CAS Google Scholar
Mukhamedova N, Hoang A, Cui HL, Carmichael I, Fu Y, Bukrinsky M, et al. Small GTPase ARF6 regulates endocytic pathway leading to degradation of ATP-binding cassette transporter A1. Arterioscler Thromb Vasc Biol. 2016;36:2292–303. https://doi.org/10.1161/atvbaha.116.308418.
Article PubMed PubMed Central CAS Google Scholar
Murtagh Jr JJ, Mowatt MR, Lee CM, Lee FJ, Mishima K, Nash TE, et al. Guanine nucleotide-binding proteins in the intestinal parasite Giardia lamblia. Isolation of a gene encoding an approximately 20-kDa ADP-ribosylation factor. J Biol Chem. 1992;267:9654–62.
PubMed CAS Google Scholar
Naslavsky N, Weigert R, Donaldson JG. Characterization of a nonclathrin endocytic pathway: membrane cargo and lipid requirements. Mol Biol Cell. 2004;15:3542–52. https://doi.org/10.1091/mbc.E04-02-0151.
Article PubMed PubMed Central CAS Google Scholar
Palacios F, Schweitzer JK, Boshans RL, D’Souza-Schorey C. ARF6-GTP recruits Nm23-H1 to facilitate dynamin-mediated endocytosis during adherens junctions disassembly. Nat Cell Biol. 2002;4:929–36. https://doi.org/10.1038/ncb881.
Article PubMed CAS Google Scholar
Paleotti O, Macia E, Luton F, Klein S, Partisani M, Chardin P, et al. The small G-protein Arf6GTP recruits the AP-2 adaptor complex to membranes. J Biol Chem. 2005;280:21661–6. https://doi.org/10.1074/jbc.M503099200.
Article PubMed CAS Google Scholar
Pasqualato S, Menetrey J, Franco M, Cherfils J. The structural GDP/GTP cycle of human Arf6. EMBO Rep. 2001;2:234–8. https://doi.org/10.1093/embo-reports/kve043.
Article PubMed PubMed Central CAS Google Scholar
Pelletan LE, Suhaiman L, Vaquer CC, Bustos MA, De Blas GA, Vitale N, et al. ADP ribosylation factor 6 (ARF6) promotes acrosomal exocytosis by modulating lipid turnover and Rab3A activation. J Biol Chem. 2015;290:9823–41. https://doi.org/10.1074/jbc.M114.629006.
Article PubMed PubMed Central CAS Google Scholar
Peters PJ, Hsu VW, Ooi CE, Finazzi D, Teal SB, Oorschot V, et al. Overexpression of wild-type and mutant ARF1 and ARF6: distinct perturbations of nonoverlapping membrane compartments. J Cell Biol. 1995;128:1003–17. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7896867.
Article PubMed CAS Google Scholar
Powelka AM, Sun J, Li J, Gao M, Shaw LM, Sonnenberg A, et al. Stimulation-dependent recycling of integrin beta1 regulated by ARF6 and Rab11. Traffic (Copenhagen, Denmark). 2004;5:20–36.
Article CAS Google Scholar
Radhakrishna H, Al-Awar O, Khachikian Z, Donaldson JG. ARF6 requirement for Rac ruffling suggests a role for membrane trafficking in cortical actin rearrangements. J Cell Sci. 1999;112(Pt 6):855–66.
PubMed CAS Google Scholar
Randazzo PA, Yang YC, Rulka C, Kahn RA. Activation of ADP-ribosylation factor by Golgi membranes. Evidence for a brefeldin A- and protease-sensitive activating factor on Golgi membranes. J Biol Chem. 1993;268:9555–63. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8486645.
Roth MG. Molecular mechanisms of PLD function in membrane traffic. Traffic (Copenhagen, Denmark). 2008;9:1233–9. https://doi.org/10.1111/j.1600–0854.2008.00742.x.
Article CAS Google Scholar
Sakagami H, Hara Y, Fukaya M. Interaction of serologically defined colon cancer antigen-3 with Arf6 and its predominant expression in the mouse testis. Biochem Biophys Res Commun. 2016;477:868–73. https://doi.org/10.1016/j.bbrc.2016.06.150.
Article PubMed CAS Google Scholar
Santy LC, Casanova JE. Activation of ARF6 by ARNO stimulates epithelial cell migration through downstream activation of both Rac1 and phospholipase D. J Cell Biol. 2001;154:599–610. https://doi.org/10.1083/jcb.200104019.
Article PubMed PubMed Central CAS Google Scholar
Santy LC, Ravichandran KS, Casanova JE. The DOCK180/Elmo complex couples ARNO-mediated Arf6 activation to the downstream activation of Rac1. Curr Biol. 2005;15:1749–54. https://doi.org/10.1016/j.cub.2005.08.052.
Article PubMed CAS Google Scholar
Scholz R, Berberich S, Rathgeber L, Kolleker A, Kohr G, Kornau HC. AMPA receptor signaling through BRAG2 and Arf6 critical for long-term synaptic depression. Neuron. 2010;66:768–80. https://doi.org/10.1016/j.neuron.2010.05.003.
Article PubMed CAS Google Scholar
Schweitzer JK, D’Souza-Schorey C. Localization and activation of the ARF6 GTPase during cleavage furrow ingression and cytokinesis. J Biol Chem. 2002;277:27210–6. https://doi.org/10.1074/jbc.M201569200.
Article PubMed CAS Google Scholar
Sewell JL, Kahn RA. Sequences of the bovine and yeast ADP-ribosylation factor and comparison to other GTP-binding proteins. Proc Natl Acad Sci USA. 1988;85:4620–4.
Article PubMed PubMed Central CAS Google Scholar
Stearns T, Willingham MC, Botstein D, Kahn RA. ADP-ribosylation factor is functionally and physically associated with the Golgi complex. Proc Natl Acad Sci USA. 1990;87:1238–42. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=2105501.
Article CAS Google Scholar
Tagliatti E, Fadda M, Falace A, Benfenati F, Fassio A. Arf6 regulates the cycling and the readily releasable pool of synaptic vesicles at hippocampal synapse. eLife. 2016;5:e10116. https://doi.org/10.7554/eLife.10116.
Article PubMed PubMed Central Google Scholar
Tsuchiya M, Price SR, Tsai SC, Moss J, Vaughan M. Molecular identification of ADP-ribosylation factor mRNAs and their expression in mammalian cells. J Biol Chem. 1991;266:2772–7. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=1993656.
Ueda T, Hanai A, Takei T, Kubo K, Ohgi M, Sakagami H, et al. EFA6 activates Arf6 and participates in its targeting to the Flemming body during cytokinesis. FEBS Lett. 2013;587:1617–23. https://doi.org/10.1016/j.febslet.2013.03.042.
Article PubMed CAS Google Scholar
Urban AE, Quick EO, Miller KP, Krcmery J, Simon H-G. Pdlim7 regulates Arf6-dependent actin dynamics and is required for platelet-mediated thrombosis in mice. PLoS One. 2016;11:e0164042. https://doi.org/10.1371/journal.pone.0164042.
Article PubMed PubMed Central CAS Google Scholar
Venkateswarlu K, Cullen PJ. Signalling via ADP-ribosylation factor 6 lies downstream of phosphatidylinositide 3-kinase. Biochem J. 2000;345(Pt 3):719–24.
Article PubMed PubMed Central CAS Google Scholar
Yamauchi Y, Miura Y, Kanaho Y. Machineries regulating the activity of the small GTPase Arf6 in cancer cells are potential targets for developing innovative anti-cancer drugs. Adv Biol Regulation. 2016;S2212-4926(16):30060–4. https://doi.org/10.1016/j.jbior.2016.10.004.
Article CAS Google Scholar
Yoo JH, Shi DS, Grossmann AH, Sorensen LK, Tong Z, Mleynek TM, et al. ARF6 is an actionable node that orchestrates oncogenic GNAQ signaling in uveal melanoma. Cancer Cell. 2016;29:889–904. https://doi.org/10.1016/j.ccell.2016.04.015.
Article PubMed PubMed Central CAS Google Scholar

Download references

Author information

Authors and Affiliations

Institute of Life Science 1, School of Medicine, Swansea University, Swansea, Wales, SA2 8PP, UK
Salman Tamaddon-Jahromi & Venkateswarlu Kanamarlapudi

Authors

Salman Tamaddon-Jahromi
View author publications
You can also search for this author in PubMed Google Scholar
Venkateswarlu Kanamarlapudi
View author publications
You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Venkateswarlu Kanamarlapudi .

Editor information

Editors and Affiliations

Department of Molecular Science and Technology, Ajou University, Suwon, Korea
Sangdun Choi

Rights and permissions

Reprints and permissions

Copyright information

About this entry

Cite this entry

Tamaddon-Jahromi, S., Kanamarlapudi, V. (2018). ADP-Ribosylation Factor-6 (ARF6). In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101965

Download citation

DOI: https://doi.org/10.1007/978-3-319-67199-4_101965
Published: 01 June 2018
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-67198-7
Online ISBN: 978-3-319-67199-4
eBook Packages: Biomedical and Life SciencesReference Module Biomedical and Life Sciences

Publish with us

Policies and ethics