Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Calcineurin

Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101959

Synonyms

Historical Background

The serine-/threonine-specific protein phosphatase calcineurin is conserved from yeast to man and was first detected in bovine brain extracts by Wang and Desai and independently by Watterson and Vanaman in 1976 (Wang and Desai 1976; Watterson and Vanaman 1976). Klee and Krinks were the first to purify calcineurin in 1978 (Klee and Krinks 1978), and Klee also coined the name “calcineurin,” since the protein was extracted from brain tissue and it could bind Ca2+ (Klee et al. 1979). However, the function of calcineurin was not known at this time. It was assumed that calcineurin might be a regulatory subunit of the phosphodiesterase, as it could inhibit phosphodiesterase activity. In the early 1980s, the real function as a phosphatase was demonstrated. Stewart et al. found that the protein phosphatase 2B isolated from rabbit skeletal muscle was identical to the previously identified calcineurin...

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References

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Institute for Biology – Microbiology, Department of Biology, Chemistry, PharmacyFreie Universität BerlinBerlinGermany