“Colony-stimulating factors” were first described in the 1960s as soluble agents that mediated the growth of colonies in soft agar from bone marrow cells. One of these was called granulocyte colony-stimulating factor (G-CSF) due to its propensity to induce colonies composed of neutrophilic granulocytes. The purification, sequencing, and cloning of this factor led to the production of recombinant G-CSF that facilitated the identification of a specific cell-surface receptor through expression library screening (Fukunaga et al. 1990). This protein was named granulocyte colony-stimulating factor receptor (G-CSFR), although the gene has now been officially designated colony-stimulating factor 3 receptor (CSF3R).
G-CSFR Evolution and Structure
G-CSFR is a member of the class I cytokine receptor superfamily. These molecules emerged...
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