Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Vinculin (VCL)

  • Christy HeidemaEmail author
  • Kris A. DeMaliEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101953


 CMD1W;  CMH15;  Metavinculin;  MVCL;  VCL

Historical Background

In 1979, Benjamin Geiger isolated a 130 kD protein from chicken gizzard that localized to the ventral surface of cells and to areas of cell-cell contact (Geiger 1979). About the same time, Keith Burridge and colleagues isolated a 130 kD, also from chicken gizzard (Burridge and Feramisco 1980). Burridge observed fluorescently labeled versions of this protein extensively co-localized with fibronectin and actin, suggesting a possible role in the organization of actin filaments at membrane attachment sites. Based on this information, the novel protein was named vinculin from the Latin word vinculum, which means a “bond” or “link.”

After its identification, many early studies reinforced the initial idea that vinculin links actin to attachment sites. Key among these was the identification of vinculin as a direct binding partner for actin and for talin – a new protein found to interacted with the integrins (Burridge and...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of BiochemistryUniversity of Iowa Roy J. and Lucille A. Carver College of MedicineIowa CityUSA
  2. 2.Interdisciplinary Graduate Program in Molecular and Cellular Biology (MCB)University of IowaIowa CityUSA