The transient receptor potential (TRP) channels play a diverse range of essential roles in the sensory systems of various species, including both invertebrates and vertebrates. The TRP channel was first identified as a molecule required for proper light response in Drosophila melanogaster. Thereafter, a series of TRP family proteins have been identified. Recently, TRPM1, the founding member of the melanoma-related transient receptor potential (TRPM) subfamily, was shown to be required for the photoresponse in mouse retinal ON bipolar cells. It further proved that TRPM1 is a component of the transduction cation channel negatively regulated by the metabotropic glutamate receptor 6 (mGluR6) cascade in ON bipolar cells through a reconstitution experiment using CHO cells expressing TRPM1, mGluR6, and Goα. In addition to the function of visual...
TRPM1-related work conducted in the authors’ laboratory is supported by the CREST from Japan Science and Technology Agency, Grant-in-Aid for Scientific Research (B), Takeda Science Foundation, Koyanagi Foundation, and Terumo Foundation for Life Science and Arts Life Science support program.
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