ZEB1 (Zinc Finger E-Box Binding Homeobox 1)
Zinc finger E-box binding homeobox 1 (ZEB1) is a zinc finger and homeodomain transcription factor playing a key role in epithelial-to-mesenchymal transition (EMT) during embryogenesis by controlling cell behavior and cell adhesion. ZEB1 has also been extensively studied in the context of tumor progression as many cancer types reactivate embryonic EMT programs to promote metastasis. Besides EMT-related programs in embryonic and pathological contexts, ZEB1 plays a key role during differentiation of a wide variety of cell types. ZEB1 was first reported in 1991 as δEF1, a transcriptional repressor of the δ1-crystalline enhancer in chicken during lens development (Funahashi et al. 1991). Independently, ZEB1 was described as...