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Urocortin

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Encyclopedia of Signaling Molecules

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References

  • Adão R, Santos-Ribeiro D, Rademaker MT, Leite-Moreira AF, Brás-Silva C. Urocortin 2 in cardiovascular health and disease. Drug Discov Today. 2015;20(7):906–14. https://doi.org/10.1016/j.drudis.2015.02.012.

    Article  PubMed  CAS  Google Scholar 

  • Baigent SM, Lowry PJ. mRNA expression profiles for corticotrophin releasing factor (CRF), urocortin, CRF receptors and CRF-binding protein in peripheral rat tissues. J Mol Endocrinol. 2000;25:43–52.

    Article  PubMed  CAS  Google Scholar 

  • Calderon-Sanchez E, Delgado C, Ruiz-Hurtado G, Domínguez-Rodríguez A, Cachofeiro V, Rodríguez-Moyano M, Gomez AM, Ordóñez A, Smani T. Urocortin induces positive inotropic effect in rat heart. Cardiovasc Res. 2009;83:717–25. https://doi.org/10.1093/cvr/cvp161.

    Article  PubMed  CAS  Google Scholar 

  • Calderón-Sánchez E, Díaz I, Ordóñez A, Smani T. Urocortin-1 mediated cardioprotection involves XIAP and CD40-ligand recovery: role of EPAC2 and ERK1/2. PLoS One. 2016;11(2):e0147375. https://doi.org/10.1371/journal.pone.0147375.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Chen A, Blount A, Vaughan J, Brar B, Vale W. Urocortin II gene is highly expressed in mouse skin and skeletal muscle tissues: localization, basal expression in CRF1 and CRF2-null mice and regulation by glucocorticoids. Endocrinology. 2004;145:2445–57.

    Article  PubMed  CAS  Google Scholar 

  • Dautzenberg FM, Hauger RL. The CRF peptide family and their receptors: yet more partners discovered. Trends Pharmacol Sci. 2002;23(2):71–7.

    Article  PubMed  CAS  Google Scholar 

  • Davidson SM, Rybka AE, Townsend PA. The powerful cardioprotective effects of urocortin and the corticotropin releasing hormone (CRH) family. Biochem Pharmacol. 2009;77:141–50. https://doi.org/10.1016/j.bcp.2008.08.033.

    Article  PubMed  CAS  Google Scholar 

  • Davis ME, Pemberton CJ, Yandle TG, Fisher SF, Lainchbury JG, Frampton CM, Rademaker MT, Richards M. Urocortin 2 infusion in healthy humans: hemodynamic, neurohormonal, and renal responses. J Am Coll Cardiol. 2007;49:461–71.

    Article  PubMed  CAS  Google Scholar 

  • Diaz I, Smani T. New insights into the mechanisms underlying vascular and cardiac effects of urocortin. Curr Vasc Pharmacol. 2013;11(4):457–64.

    Article  PubMed  CAS  Google Scholar 

  • Donaldson CJ, Sutton SW, Perrin MH, Corrigan AZ, Lewis KA, Rivier JE, Vaughan JM, Vale WW. Cloning and characterization of human urocortin. Endocrinology. 1996 May;137(5):2167–70. Erratum in: Endocrinology. 1996 Sep;137(9):3896.

    Google Scholar 

  • Gao MH, Giamouridis D, Lai NC, Walenta E, Paschoal VA, Kim YC, Miyanohara A, Guo T, Liao M, Liu L, Tan Z, Ciaraldi TP, Schenk S, Bhargava A, Oh DY, Hammond HK. One-time injection of AAV8 encoding urocortin 2 provides long-term resolution of insulin resistance. JCI Insight. 2016;1(15):e88322.

    Article  PubMed  PubMed Central  Google Scholar 

  • Henckens MJ, Deussing JM, Chen A. Region-specific roles of the corticotropin-releasing factor-urocortin system in stress. Nat Rev Neurosci. 2016;17(10):636–51. https://doi.org/10.1038/nrn.2016.94.

    Article  PubMed  CAS  Google Scholar 

  • Latchaman DS. Urocortin. Int J Biochem Cell Biol. 2002;34(8):907–10.

    Article  Google Scholar 

  • Lawrence KM, Scarabelli TM, Turtle L, Chanalaris A, Townsend PA, Carroll CJ, Hubank M, Stephanou A, Knight RA, Latchman DS. Urocortin protects cardiac myocytes from ischemia/reperfusión injury by attenuating calcium-sensitive phospholipase A2 gene expression. FASEB J. 2003;17:2313–5.

    Article  PubMed  CAS  Google Scholar 

  • Neufeld-Cohen A, Tsoory MM, Evans AK, Getselter D, Gil S, Lowry CA, Vale WW, Chen A. A triple urocortin knockout mouse model reveals an essential role for urocortins in stress recovery. Proc Natl Acad Sci USA. 2010;107(44):19020–5.

    Article  PubMed  PubMed Central  Google Scholar 

  • Pan W, Kastin AJ. Urocortin and the brain. Prog Neurobiol. 2008;84(2):148–56.

    Article  PubMed  CAS  Google Scholar 

  • Reutenauer-Patte J, Boittin FX, Patthey-Vuadens O, Ruegg UT, Dorchies OM. Urocortins improve dystrophic skeletal muscle structure and function through both PKA- and Epac-dependent pathways. Am J Pathol. 2012;180(2):749–62. https://doi.org/10.1016/j.ajpath.2011.10.038.

    Article  PubMed  CAS  Google Scholar 

  • Smani T, Calderon E, Rodriguez-Moyano M, Dominguez-Rodriguez A, Diaz I, Ordóñez A. Urocortin-2 induces vasorelaxation of coronary arteries isolated from patients with heart failure. Clin Exp Pharmacol Physiol. 2011;38(1):71–6. https://doi.org/10.1111/j.1440-1681.2010.05466.x.

    Article  PubMed  CAS  Google Scholar 

  • Vale W, Spiess J, Rivier C, Rivier J. Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin. Science. 1981;213:1394–7.

    Article  PubMed  CAS  Google Scholar 

  • Vaughan J, Donaldson C, Bittencourt J, Perrin MH, Lewis K, Sutton S, Chan R, Turnbull AV, Lovejoy D, Rivier C, Rivier J, Sawchenko PE, Vale W. Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor. Nature. 1995;378:287–92.

    Article  PubMed  CAS  Google Scholar 

  • Wiley KE, Davenport AP. CRF2 receptors are highly expressed in the human cardiovascular system and their cognate ligands urocortins 2 and 3 are potent vasodilators. Br J Pharmacol. 2004;143:508–14.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

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Authors and Affiliations

  1. Grupo de Fisiopatología Cardiovascular, Lab 113, Instituto de Biomedicina de Sevilla/Hospital Universitario Virgen del Rocío, Avenida Manuel Siurot s/n, 41013, Sevilla, Spain

    Tarik Smani

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  1. Tarik Smani
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Correspondence to Tarik Smani .

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Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Smani, T. (2018). Urocortin. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101942

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