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SLC9

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References

  • Bell SM, Schreiner CM, Schultheis PJ, Miller ML, Evans RL, Vorhees CV, et al. Targeted disruption of the murine Nhe1 locus induces ataxia, growth retardation, and seizures. Am J Phys. 1999;276:C788–95.

    Article  CAS  Google Scholar 

  • Christianson AL, Stevenson RE, van der Meyden CH, Pelser J, Theron FW, van Rensburg PL, et al. X linked severe mental retardation, craniofacial dysmorphology, epilepsy, ophthalmoplegia, and cerebellar atrophy in a large South African kindred is localised to Xq24-q27. J Med Genet. 1999;36:759–66.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Donowitz M, Ming Tse C, Fuster D. SLC9/NHE gene family, a plasma membrane and organellar family of Na(+)/H(+) exchangers. Mol Asp Med. 2013;34:236–51. doi:10.1016/j.mam.2012.05.001.

    Article  CAS  Google Scholar 

  • Garbern JY, Neumann M, Trojanowski JQ, Lee VM, Feldman G, Norris JW, et al. A mutation affecting the sodium/proton exchanger, SLC9A6, causes mental retardation with tau deposition. Brain. 2010;133:1391–402. doi:10.1093/brain/awq071.

    Article  PubMed  PubMed Central  Google Scholar 

  • Gilfillan GD, Selmer KK, Roxrud I, Smith R, Kyllerman M, Eiklid K, et al. SLC9A6 mutations cause X-linked mental retardation, microcephaly, epilepsy, and ataxia, a phenotype mimicking Angelman syndrome. Am J Hum Genet. 2008;82:1003–10. doi:10.1016/j.ajhg.2008.01.013.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Hunte C, Screpanti E, Venturi M, Rimon A, Padan E, Michel H. Structure of a Na+/H+ antiporter and insights into mechanism of action and regulation by pH. Nature. 2005;435:1197–202. doi:10.1038/nature03692.

    Article  PubMed  CAS  Google Scholar 

  • Kondapalli KC, Hack A, Schushan M, Landau M, Ben-Tal N, Rao R. Functional evaluation of autism-associated mutations in NHE9. Nat Commun. 2013;4:2510. doi:10.1038/ncomms3510.

    Article  PubMed  CAS  Google Scholar 

  • Landau M, Herz K, Padan E, Ben-Tal N. Model structure of the Na+/H+ exchanger 1 (NHE1) – functional and clinical implications. J Biol Chem. 2007;282:37854–63. doi:10.1074/jbc.M705460200.

    Article  PubMed  CAS  Google Scholar 

  • Milosavljevic N, Monet M, Lena I, Brau F, Lacas-Gervais S, Feliciangeli S, et al. The intracellular Na(+)/H(+) exchanger NHE7 effects a Na(+)-coupled, but not K(+)-coupled proton-loading mechanism in endocytosis. Cell Rep. 2014;7:689–96. doi:10.1016/j.celrep.2014.03.054.

    Article  PubMed  CAS  Google Scholar 

  • Morrow EM, Yoo SY, Flavell SW, Kim TK, Lin Y, Hill RS, et al. Identifying autism loci and genes by tracing recent shared ancestry. Science. 2008;321:218–23. doi:10.1126/science.1157657.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Nygaard EB, Lagerstedt JO, Bjerre G, Shi B, Budamagunta M, Poulsen KA, et al. Structural modeling and electron paramagnetic resonance spectroscopy of the human Na+/H+ exchanger isoform 1, NHE1. J Biol Chem. 2011;286:634–48. doi:10.1074/jbc.M110.159202.

    Article  PubMed  CAS  Google Scholar 

  • Orlowski J, Grinstein S. Na+/H+ exchangers. Compr Physiol. 2011;1:2083–100. doi:10.1002/cphy.c110020.

    Article  PubMed  Google Scholar 

  • Padan E, Landau M. Sodium-Proton (Na+/H+) antiporters: properties and roles in health and disease. In: Sigel A, Sigel H, Sigel RKO, editors. The alkali metal ions: their role for life. Cham: Springer International Publishing; 2016. p. 391–458.

    Chapter  Google Scholar 

  • Schwede M, Garbett K, Mirnics K, Geschwind DH, Morrow EM. Genes for endosomal NHE6 and NHE9 are misregulated in autism brains. Mol Psychiatry. 2014;19:277–9. doi:10.1038/mp.2013.28.

    Article  PubMed  CAS  Google Scholar 

  • Slepkov ER, Rainey JK, Li X, Liu Y, Cheng FJ, Lindhout DA, et al. Structural and functional characterization of transmembrane segment IV of the NHE1 isoform of the Na+/H+ exchanger. J Biol Chem. 2005;280:17863–72.

    Article  PubMed  CAS  Google Scholar 

  • Stromme P, Dobrenis K, Sillitoe RV, Gulinello M, Ali NF, Davidson C, et al. X-linked Angelman-like syndrome caused by Slc9a6 knockout in mice exhibits evidence of endosomal-lysosomal dysfunction. Brain. 2011;134:3369–83. doi:10.1093/brain/awr250.

    Article  PubMed  PubMed Central  Google Scholar 

  • Wakabayashi S, Pang T, Su X, Shigekawa M. A novel topology model of the human Na(+)/H(+) exchanger isoform 1. J Biol Chem. 2000;275:7942–9.

    Article  PubMed  CAS  Google Scholar 

  • Wakabayashi S, Hisamitsu T, Nakamura TY. Regulation of the cardiac Na(+)/H(+) exchanger in health and disease. J Mol Cell Cardiol. 2013;61:68–76. doi:10.1016/j.yjmcc.2013.02.007.

    Article  PubMed  CAS  Google Scholar 

  • West IC, Mitchell P. Proton/sodium ion antiport in Escherichia coli. Biochem J. 1974;144:87–90.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Biology, Technion – Israel Institute of Technology, Haifa, Israel

    Meytal Landau

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  1. Meytal Landau
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Correspondence to Meytal Landau .

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Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Landau, M. (2018). SLC9. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101935

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