Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi


  • Samapika RoutrayEmail author
  • Niharika Swain
  • Rashmi Maruti Hosalkar
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101931


 BSCL3;  CAV-1;  CGL3;  LCCNS;  MSTP085;  PPH3;  VIP21

Historical Background

Caveolin-1 or Cav-1, one of three members of caveolin family, is a structural component of caveolae or “little cave”-like vesicular invaginations of plasma membrane. Based on their lipid composition and biophysical features, caveolae are considered subtypes of lipid rafts that form invaginations and are capable of endocytosis (Fig. 1). Cav-1 is the first member and true protein marker of caveolin family to be identified as tyrosine phosphorylated in Rous sarcoma virus-transformed fibroblasts in 1989 (Glenney 1989). Subsequently, other two members of the family, Caveolin-2 (Cav-2) and Caveolin-3 (Cav-3), were discovered in various experimental studies in 1996. Cav-2 was found to be colocalized and coexpressed with Cav-1 in adipocyte-derived caveolar membrane, whereas Cav-3 (M-Caveolin) was identified as an attempt to find Cav-1 homologs through database search and cDNA library screening (Williams and...
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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Samapika Routray
    • 1
    Email author
  • Niharika Swain
    • 2
  • Rashmi Maruti Hosalkar
    • 3
    • 4
  1. 1.Department of Dental SurgeryAll India Institute of Medical SciencesBhubaneswarIndia
  2. 2.MGM Dental College and HospitalNavi MumbaiIndia
  3. 3.Indian Association of Oral and Maxillofacial PathologistsMumbaiIndia
  4. 4.Maharashtra State Dental CouncilMumbaiIndia