Reference work entry
Caveolin-1 or Cav-1, one of three members of caveolin family, is a structural component of caveolae or “little cave”-like vesicular invaginations of plasma membrane. Based on their lipid composition and biophysical features, caveolae are considered subtypes of lipid rafts that form invaginations and are capable of endocytosis (Fig. 1). Cav-1 is the first member and true protein marker of caveolin family to be identified as tyrosine phosphorylated in Rous sarcoma virus-transformed fibroblasts in 1989 (Glenney 1989). Subsequently, other two members of the family, Caveolin-2 (Cav-2) and Caveolin-3 (Cav-3), were discovered in various experimental studies in 1996. Cav-2 was found to be colocalized and coexpressed with Cav-1 in adipocyte-derived caveolar membrane, whereas Cav-3 (M-Caveolin) was identified as an attempt to find Cav-1 homologs through database search and cDNA library screening (Williams and...
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