Tumor Protein D52 (TPD52)
Mammalian TPD52 sequences were first described in the mid-1990s, through a number of independent reports and experimental approaches. Publications from 1995 to 1996 identified TPD52 sequences through the detection of increased TPD52 transcript levels in human cancer tissue or cell lines, relative to nonmalignant controls. Orthologous rat, rabbit, or quail transcripts were identified as either encoding proteins that are phosphorylated in response to raised intracellular calcium levels or as a retroviral target gene, respectively. Early reports also identified paralogous human and mouse transcript sequences, and these reports, combined with genome sequencing, demonstrated that TPD52 is one gene within a four-member gene family (reviewed by Boutros et al. 2004; Byrne et al. 2014). While TPD52-like protein sequences are...
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