Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Thyrotropin Receptor

  • Samer El-KaissiEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101925


Historical Background

The thyrotropin receptor (TSHR) is a seven-transmembrane protein that belongs to the family of G-protein-coupled receptors (GPCR). The receptor is located on the surface of thyroid follicular cells, and its activation leads to thyroid hormone production and growth and proliferation of thyrocytes.

The primary activator of the TSHR is the thyroid-stimulating hormone (TSH) or thyrotropin, although the receptor may also be activated by stimulating antibodies as occurs in autoimmune hyperthyroidism, known as Graves’ disease. The TSHR is expressed in many non-thyroidal tissues and may be involved in the systemic manifestations of thyroid disease, such as thyroid-associated ophthalmopathy, pretibial myxedema, and metabolic bone disease.

Structurally, the TSHR can...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Medical Subspecialties InstituteCleveland Clinic Abu DhabiAbu DhabiUAE