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Encyclopedia of Signaling Molecules pp 5884–5892Cite as

Vascular Endothelial Growth Factor Receptor (VEGFR)

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Synonyms

Vascular endothelial growth factor receptor 1 (VEGFR1): Fms-like tyrosine kinase 1 (FLT1); Tyrosine-protein kinase FRT; Tyrosine-protein kinase receptor FLT (FLT); Vascular permeability factor receptor.

Vascular endothelial growth factor receptor 2 (VEGFR2): Fetal liver kinase 1 (FLK1); Kinase insert domain receptor (KDR); Protein-tyrosine kinase receptor flk-1; CD antigen (CD309).

Vascular endothelial growth factor receptor 3 (VEGFR3): Fms-like tyrosine kinase 4 (FLT4); Tyrosine-protein kinase receptor FLT4.

Historical Background

The vascular endothelial growth factor receptors (VEGFRs) are a family of receptor tyrosine kinases that mediate the biological functions of vascular endothelial growth factors (VEGFs), thereby playing key roles in vascular development. Following the discovery and cloning of VEGF, later denoted as VEGFA, as a potent inducer of vascular permeability and angiogenesis, VEGFR1 (alternatively denoted fms-like tyrosine kinase 1 (FLT1) in mouse) was first...

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Authors and Affiliations

  1. Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, 75185, Uppsala, Sweden

    Roberta Lugano, Hua Huang & Anna Dimberg

Authors
  1. Roberta Lugano
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  2. Hua Huang
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  3. Anna Dimberg
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Corresponding authors

Correspondence to Roberta Lugano , Hua Huang or Anna Dimberg .

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Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Lugano, R., Huang, H., Dimberg, A. (2018). Vascular Endothelial Growth Factor Receptor (VEGFR). In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101914

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