Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Transient Receptor Potential Cation Channel Subfamily M Member 7

  • Nelson S. YeeEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101913


Historical Background

Transient receptor potential (TRP) is a superfamily of channels that control the passage of cations across biological membranes (Yee et al. 2014). The TRP members share common features including intracellular amino and carboxyl termini, six transmembrane segments with the peptide between segments 5 and 6 forming the channel pore, and the TRP domain consisting of 23–25 amino acids highly conserved among all TRP members. TRP proteins are expressed in both electrically nonexcitable and excitable cells. TRP channels can be activated by changes in voltage or temperature, by ligand binding, or through covalent modification of amino acid residues. Channel activation...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of Medicine, Division of Hematology-OncologyPennsylvania State University, Milton S. Hershey Medical Center, PennState Cancer InstituteHersheyUSA