Skip to main content
SpringerLink
Log in

TRPV6

  • Reference work entry
  • First Online:
Encyclopedia of Signaling Molecules

  • 226 Accesses

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 4,499.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 4,499.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Akey JM, Swanson WJ, Madeoy J, Eberle M, Shriver MD. TRPV6 exhibits unusual patterns of polymorphism and divergence in worldwide populations. Hum Mol Genet. 2006;15:2106–13.

    Article  PubMed  CAS  Google Scholar 

  • Bianco SD, Peng JB, Takanaga H, Suzuki Y, Crescenzi A, Kos CH, Zhuang L, Freeman MR, Gouveia CH, Wu J, Luo H, Mauro T, Brown EM, Hediger MA. Marked disturbance of calcium homeostasis in mice with targeted disruption of the Trpv6 calcium channel gene. J Bone Miner Res. 2007;22:274–85.

    Article  PubMed  CAS  Google Scholar 

  • Bolanz KA, Hediger MA, Landowski CP. The role of TRPV6 in breast carcinogenesis. Mol Cancer Ther. 2008;7:271–9.

    Article  PubMed  CAS  Google Scholar 

  • Bolanz KA, Kovacs GG, Landowski CP, Hediger MA. Tamoxifen inhibits TRPV6 activity via estrogen receptor-independent pathways in TRPV6-expressing MCF-7 breast cancer cells. Mol Cancer Res. 2009;7:2000–10.

    Article  PubMed  CAS  Google Scholar 

  • Bowen CV, DeBay D, Ewart HS, Gallant P, Gormley S, Ilenchuk TT, Iqbal U, Lutes T, Martina M, Mealing G, Merkley N, Sperker S, Moreno MJ, Rice C, Syvitski RT, Stewart JM. In vivo detection of human TRPV6-rich tumors with anti-cancer peptides derived from soricidin. PloS one. 2013;8:e58866.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Caramelli D, Lalueza-Fox C, Vernesi C, Lari M, Casoli A, Mallegni F, Chiarelli B, Dupanloup I, Bertranpetit J, Barbujani G, Bertorelle G. Evidence for a genetic discontinuity between Neandertals and 24,000-year-old anatomically modern Europeans. Proc Natl Acad Sci USA. 2003;100:6593–7.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Caterina MJ, Rosen TA, Tominaga M, Brake AJ, Julius D. A capsaicin-receptor homologue with a high threshold for noxious heat. Nature. 1999;398:436–41.

    Article  CAS  PubMed  Google Scholar 

  • Chang Q, Hoefs S, van der Kemp AW, Topala CN, Bindels RJ, Hoenderop JG. The beta-glucuronidase klotho hydrolyzes and activates the TRPV5 channel. Science. 2005;310:490–3.

    Article  PubMed  CAS  Google Scholar 

  • Chen F, Ni B, Yang YO, Ye T, Chen A. Knockout of TRPV6 causes osteopenia in mice by increasing osteoclastic differentiation and activity. Cell Physiol Biochem. 2014;33:796–809.

    Article  PubMed  CAS  Google Scholar 

  • Erler I, Hirnet D, Wissenbach U, Flockerzi V, Niemeyer BA. Ca2+−selective transient receptor potential V channel architecture and function require a specific ankyrin repeat. J Biol Chem. 2004;279:34456–63.

    Article  PubMed  CAS  Google Scholar 

  • Fecher-Trost C, Wissenbach U, Beck A, Schalkowsky P, Stoerger C, Doerr J, Dembek A, Simon-Thomas M, Weber A, Wollenberg P, Ruppert T, Middendorff R, Maurer HH, Flockerzi V. The in vivo TRPV6 protein starts at a non-AUG triplet, decoded as methionine, upstream of canonical initiation at AUG. J Biol Chem. 2013;288:16629–44.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Fixemer T, Wissenbach U, Flockerzi V, Bonkhoff H. Expression of the Ca2+−selective cation channel TRPV6 in human prostate cancer: a novel prognostic marker for tumor progression. Oncogene. 2003;22:7858–61.

    Article  PubMed  CAS  Google Scholar 

  • Haverstick DM, Heady TN, Macdonald TL, Gray LS. Inhibition of human prostate cancer proliferation in vitro and in a mouse model by a compound synthesized to block Ca2+ entry. Cancer Res. 2000;60:1002–8.

    PubMed  CAS  Google Scholar 

  • Hirnet D, Olausson J, Fecher-Trost C, Bodding M, Nastainczyk W, Wissenbach U, Flockerzi V, Freichel M. The TRPV6 gene, cDNA and protein. Cell Calcium. 2003;33:509–18.

    Article  PubMed  CAS  Google Scholar 

  • Hoenderop JG, van der Kemp AW, Hartog A, van de Graaf SF, van Os CH, Willems PH, Bindels RJ. Molecular identification of the apical Ca2+ channel in 1, 25-dihydroxyvitamin D3-responsive epithelia. J Biol Chem. 1999;274:8375–8.

    Article  PubMed  CAS  Google Scholar 

  • Hoenderop JG, Vennekens R, Muller D, Prenen J, Droogmans G, Bindels RJ, Nilius B. Function and expression of the epithelial Ca(2+) channel family: comparison of mammalian ECaC1 and 2. J Physiol. 2001;537:747–61.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Hoenderop JG, Voets T, Hoefs S, Weidema F, Prenen J, Nilius B, Bindels RJ. Homo- and heterotetrameric architecture of the epithelial Ca2+ channels TRPV5 and TRPV6. EMBO J. 2003;22:776–85.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Hofmann L, Wang H, Beck A, Wissenbach U, Flockerzi V. A conserved gating element in TRPV6 channels. Cell Calcium. 2016. https://doi.org/10.1074/jbc.M113.478305.

    Article  PubMed  Google Scholar 

  • Hughes DA, Tang K, Strotmann R, Schoneberg T, Prenen J, Nilius B, Stoneking M. Parallel selection on TRPV6 in human populations. PloS one. 2008;3:e1686.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Kessler T, Wissenbach U, Grobholz R, Flockerzi V. TRPV6 alleles do not influence prostate cancer progression. BMC Cancer. 2009;9:380.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Kovacs G, Montalbetti N, Simonin A, Danko T, Balazs B, Zsembery A, Hediger MA. Inhibition of the human epithelial calcium channel TRPV6 by 2-aminoethoxydiphenyl borate (2-APB). Cell Calcium. 2012;52:468–80.

    Article  PubMed  CAS  Google Scholar 

  • Landowski CP, Bolanz KA, Suzuki Y, Hediger MA. Chemical inhibitors of the calcium entry channel TRPV6. Pharm Res. 2011;28:322–30.

    Article  PubMed  CAS  Google Scholar 

  • Luo H, Yu G, Tremblay J, Wu J. EphB6-null mutation results in compromised T cell function. J Clin Invest. 2004;114:1762–73.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • McNicholas S, Potterton E, Wilson KS, Noble MEM. Presenting your structures: the CCP4mg molecular-graphics software. Acta Cryst. 2011;D67:386–94.

    Google Scholar 

  • Merchant SS, Prochnik SE, Vallon O, Harris EH, Karpowicz SJ, Witman GB, Terry A, Salamov A, Fritz-Laylin LK, Marechal-Drouard L, Marshall WF, Qu LH, Nelson DR, Sanderfoot AA, Spalding MH, Kapitonov VV, Ren Q, Ferris P, Lindquist E, Shapiro H, Lucas SM, Grimwood J, Schmutz J, Cardol P, Cerutti H, Chanfreau G, Chen CL, Cognat V, Croft MT, Dent R, Dutcher S, Fernandez E, Fukuzawa H, Gonzalez-Ballester D, Gonzalez-Halphen D, Hallmann A, Hanikenne M, Hippler M, Inwood W, Jabbari K, Kalanon M, Kuras R, Lefebvre PA, Lemaire SD, Lobanov AV, Lohr M, Manuell A, Meier I, Mets L, Mittag M, Mittelmeier T, Moroney JV, Moseley J, Napoli C, Nedelcu AM, Niyogi K, Novoselov SV, Paulsen IT, Pazour G, Purton S, Ral JP, Riano-Pachon DM, Riekhof W, Rymarquis L, Schroda M, Stern D, Umen J, Willows R, Wilson N, Zimmer SL, Allmer J, Balk J, Bisova K, Chen CJ, Elias M, Gendler K, Hauser C, Lamb MR, Ledford H, Long JC, Minagawa J, Page MD, Pan J, Pootakham W, Roje S, Rose A, Stahlberg E, Terauchi AM, Yang P, Ball S, Bowler C, Dieckmann CL, Gladyshev VN, Green P, Jorgensen R, Mayfield S, Mueller-Roeber B, Rajamani S, Sayre RT, Brokstein P, et al. The Chlamydomonas genome reveals the evolution of key animal and plant functions. Science. 2007;318:245–50.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Montell C, Birnbaumer L, Flockerzi V, Bindels RJ, Bruford EA, Caterina MJ, Clapham DE, Harteneck C, Heller S, Julius D, Kojima I, Mori Y, Penner R, Prawitt D, Scharenberg AM, Schultz G, Shimizu N, Zhu MX. A unified nomenclature for the superfamily of TRP cation channels. Mol Cell. 2002;9:229–31.

    Article  PubMed  CAS  Google Scholar 

  • Muller D, Hoenderop JG, Meij IC, van den Heuvel LP, Knoers NV, den Hollander AI, Eggert P, Garcia-Nieto V, Claverie-Martin F, Bindels RJ. Molecular cloning, tissue distribution, and chromosomal mapping of the human epithelial Ca2+ channel (ECAC1). Genomics. 2000;67:48–53.

    Article  PubMed  CAS  Google Scholar 

  • Niemeyer BA, Bergs C, Wissenbach U, Flockerzi V, Trost C. Competitive regulation of CaT-like-mediated Ca2+ entry by protein kinase C and calmodulin. Proc Natl Acad Sci USA. 2001;98:3600–5.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Nijenhuis T, Hoenderop JG, van der Kemp AW, Bindels RJ. Localization and regulation of the epithelial Ca2+ channel TRPV6 in the kidney. J Am Soc Nephrol. 2003;14:2731–40.

    Article  PubMed  CAS  Google Scholar 

  • Nilius B, Prenen J, Vennekens R, Hoenderop JG, Bindels RJ, Droogmans G. Pharmacological modulation of monovalent cation currents through the epithelial Ca2+ channel ECaC1. Br J Pharmacol. 2001a;134:453–62.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Nilius B, Vennekens R, Prenen J, Hoenderop JG, Droogmans G, Bindels RJ. The single pore residue Asp542 determines Ca2+ permeation and Mg2+ block of the epithelial Ca2+ channel. J Biol Chem. 2001b;276:1020–5.

    Article  PubMed  CAS  Google Scholar 

  • Peng JB. TRPV5 and TRPV6 in transcellular Ca(2+) transport: regulation, gene duplication, and polymorphisms in African populations. Adv Exp Med Biol. 2011;704:239–75.

    Article  PubMed  CAS  Google Scholar 

  • Peng JB, Chen XZ, Berger UV, Vassilev PM, Tsukaguchi H, Brown EM, Hediger MA. Molecular cloning and characterization of a channel-like transporter mediating intestinal calcium absorption. J Biol Chem. 1999;274:22739–46.

    Article  PubMed  CAS  Google Scholar 

  • Peng JB, Chen XZ, Berger UV, Vassilev PM, Brown EM, Hediger MA. A rat kidney-specific calcium transporter in the distal nephron. J Biol Chem. 2000;275:28186–94.

    PubMed  CAS  Google Scholar 

  • Pennisi E. Human evolution. Genomes throw kinks in timing of chimp-human split. Science. 2006;312:985–6.

    Article  PubMed  CAS  Google Scholar 

  • Saotome K, Singh AK, Yelshanskaya MV, Sobolevsky AI. Crystal structure of the epithelial calcium channel TRPV6. Nature. 2016;534:506–11.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Schwarz EC, Wissenbach U, Niemeyer BA, Strauss B, Philipp SE, Flockerzi V, Hoth M. TRPV6 potentiates calcium-dependent cell proliferation. Cell Calcium. 2006;39:163–73.

    Article  PubMed  CAS  Google Scholar 

  • Stringer CB, Andrews P. Genetic and fossil evidence for the origin of modern humans. Science. 1988;239:1263–8.

    Article  PubMed  CAS  Google Scholar 

  • Vassilev PM, Peng JB, Hediger MA, Brown EM. Single-channel activities of the human epithelial Ca2+ transport proteins CaT1 and CaT2. J Membr Biol. 2001;184:113–20.

    Article  PubMed  CAS  Google Scholar 

  • Vennekens R, Hoenderop JG, Prenen J, Stuiver M, Willems PH, Droogmans G, Nilius B, Bindels RJ. Permeation and gating properties of the novel epithelial Ca(2+) channel. J Biol Chem. 2000;275:3963–9.

    Article  PubMed  CAS  Google Scholar 

  • Voets T, Janssens A, Prenen J, Droogmans G, Nilius B. Mg2+-dependent gating and strong inward rectification of the cation channel TRPV6. J Gen Physiol. 2003;121:245–60.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Weissgerber P, Kriebs U, Tsvilovskyy V, Olausson J, Kretz O, Stoerger C, Vennekens R, Wissenbach U, Middendorff R, Flockerzi V, Freichel M. Male fertility depends on Ca(2)+ absorption by TRPV6 in epididymal epithelia. Sci Signal. 2011;4:ra27.

    Article  PubMed  CAS  Google Scholar 

  • Weissgerber P, Kriebs U, Tsvilovskyy V, Olausson J, Kretz O, Stoerger C, Mannebach S, Wissenbach U, Vennekens R, Middendorff R, Flockerzi V, Freichel M. Excision of Trpv6 gene leads to severe defects in epididymal Ca2+ absorption and male fertility much like single D541A pore mutation. J Biol Chem. 2012;287:17930–41.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Wissenbach U, Niemeyer BA. TRPV6. Handb Exp Pharmacol. 2007;179:221–34.

    Article  CAS  Google Scholar 

  • Wissenbach U, Niemeyer BA, Fixemer T, Schneidewind A, Trost C, Cavalie A, Reus K, Meese E, Bonkhoff H, Flockerzi V. Expression of CaT-like, a novel calcium-selective channel, correlates with the malignancy of prostate cancer. J Biol Chem. 2001;276:19461–8.

    Article  PubMed  CAS  Google Scholar 

  • Wissenbach U, Niemeyer B, Himmerkus N, Fixemer T, Bonkhoff H, Flockerzi V. TRPV6 and prostate cancer: cancer growth beyond the prostate correlates with increased TRPV6 Ca2+ channel expression. Biochem Biophys Res Commun. 2004;322:1359–63.

    Article  PubMed  CAS  Google Scholar 

  • Yue L, Peng JB, Hediger MA, Clapham DE. CaT1 manifests the pore properties of the calcium-release-activated calcium channel. Nature. 2001;410:705–9.

    Article  PubMed  CAS  Google Scholar 

  • Zhuang L, Peng JB, Tou L, Takanaga H, Adam RM, Hediger MA, Freeman MR. Calcium-selective ion channel, CaT1, is apically localized in gastrointestinal tract epithelia and is aberrantly expressed in human malignancies. Lab Invest. 2002;82:1755–64.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Experimental and Clinical Pharmacology and Toxicology, Saarland University, Universitätsklinikum Gebäude 46, 66421, Hamburg, Germany

    Ulrich Wissenbach

Authors
  1. Ulrich Wissenbach
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ulrich Wissenbach .

Editor information

Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Wissenbach, U. (2018). TRPV6. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101911

Download citation

Publish with us

Policies and ethics

Search

Navigation