Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi


  • Ulrich WissenbachEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101911


Historical Background

According to the nomenclature of transient receptor (TRP) channels TRPV6 represents the last member of the vanilloid-like TRP (TRPV) subfamily which were named after the first member TRPV1. TRPV1 can be activated by vanilloid-like compounds (Caterina et al. 1999; Montell et al. 2002). TRPV6 was first isolated from rat small intestine using a functional cloning approach (Peng et al. 1999). The human orthologue which shows only 90% identical amino acids to the rat sequence was cloned from a human placenta cDNA library (Wissenbach et al. 2001), and the mouse sequence was cloned by Hirnet and coworkers (Hirnet et al. 2003).

Properties of the TRPV6 Channel

The functional TRPV6 channel consists of four identical subunits, the four TRPV6 proteins, which form...
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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Institute of Experimental and Clinical Pharmacology and ToxicologySaarland UniversityHamburgGermany