Historical Background
TRPC5 is a member of the canonical family of transient receptor potential (TRP) channels, forming a subgroup along with TRPC1 and TRPC4. TRPC5 has been cloned from the mouse (Okada et al. 1998; Philipp et al. 1998), rabbit (Philipp et al. 1998), and humans, lying in the Xq23 region of the latter, a region that contains loci for nonsyndromic mental retardation and two genes implicated in X-linked disorders. The TRPC5 protein forms homomers and heteromers with TRPC1, TRPC3, TRPC4, and TRPC6 (Strubing et al. 2001). Like other members of the TRPC family, TRPC5 is a nonselective cationic channel that permits the flow of calcium, sodium, cesium, and potassium ions, although with greater selectivity for Ca2+. Cation selectivity varies in the literature, from PCa2+/PNa+ = 14.3 (Okada et al. 1998) to PCa2+/PNa+ = 1.79 (Schaefer et al. 2000). When...
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Arcas, J.M., Gomis, A. (2018). Transient Receptor Potential Cation Channel Subfamily C Member 5. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101908
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