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Encyclopedia of Signaling Molecules pp 5930–5941Cite as

Vitronectin

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Synonyms

Complement S-protein; Epibolin; Somatomedin B; Serum spreading factor; V75; VN; VNT; VTN

Historical Background

VN was first described as a “serum spreading factor” to promote the attachment and spreading of cells to various surfaces, and it is this property of plasma/serum that enables mammalian cells to adhere to culture dishes and propagate (Leavesley et al. 2013). Unrelated investigations in cellular movement and epiboly as well as in innate immunity lead to the term “epibolin” or the discovery of VN as the complement inhibitor “S-protein,” respectively, whereby the identity of both factors was uncovered 30 years ago by the author.

VN Gene and Expression of the VN Protein

Gene Structure

The human VN gene (about 3.5 kb) is localized on chromosome 17 (centromeric region 17q11); the murine VN gene is found on chromosome 10. Both VN genes consist of eight exons and seven introns, resulting in 1.7 kb transcripts without indication for alternative splicing (Jenne and Stanley 1987...

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References

  • Andreasen PA, Kjøller L, Christensen L, Duffy MJ. The urokinase-type plasminogen activator system in cancer metastasis: a review. Int J Cancer. 1997;72:1–22.

    Article  CAS  PubMed  Google Scholar 

  • Bergmann S, Lang A, Rohde M, Agarwal V, Rennemeier C, Grashoff C, Preissner KT, Hammerschmidt S. Integrin-linked kinase is required for vitronectin-mediated internalization of Streptococcus pneumoniae by host cells. J Cell Sci. 2009;122:256–67. https://doi.org/10.1242/jcs.035600.

    Article  CAS  PubMed  Google Scholar 

  • Chapman HA. Plasminogen activators, integrins, and the coordinated regulation of cell adhesion and migration. Curr Opin Cell Biol. 1997;9:714–24.

    Article  CAS  PubMed  Google Scholar 

  • Declerck PJ, De Mol M, Alessi MC, Baudner S, Pâques EP, Preissner KT, Müller-Berghaus G, Collen D. Purification and characterization of a plasminogen activator inhibitor 1 binding protein from human plasma. Identification as a multimeric form of S protein (vitronectin). J Biol Chem. 1988;263:15454–61.

    CAS  PubMed  Google Scholar 

  • Eitzman DT, Westrick RJ, Nabel EG, Ginsburg D. Plasminogen activator inhibitor-1 and vitronectin promote vascular thrombosis in mice. Blood. 2000;95:577–80.

    CAS  PubMed  Google Scholar 

  • Hallström T, Singh B, Kraiczy P, Hammerschmidt S, Skerka C, Zipfel PF, Riesbeck K. Conserved patterns of microbial immune escape: Pathogenic microbes of diverse origin target the human terminal complement inhibitor vitronectin via a single common motif. PLoS One. 2016;11:e0147709. https://doi.org/10.1371/journal.pone.0147709.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Harbeck N, Kates RE, Schmitt M, Gauger K, Kiechle M, Janicke F, Thomassen C, Look MP, Foekens JA. Urokinase-type plasminogen activator and its inhibitor type 1 predict disease outcome and therapy response in primary breast cancer. Clin Breast Cancer. 2004;5:348–52.

    Article  CAS  PubMed  Google Scholar 

  • Jenne D, Stanley KK. Nucleotide sequence and organization of the human S-protein gene: repeating peptide motifs in the “pexin” family and a model for their evolution. Biochemistry. 1987;26:6735–42.

    Article  CAS  PubMed  Google Scholar 

  • Kenny HA, Kaur S, Coussens LM, Lengyel E. The initial steps of ovarian cancer cell metastasis are mediated by MMP-2 cleavage of vitronectin and fibronectin. J Clin Invest. 2008;118:1367–79. https://doi.org/10.1172/JCI33775.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Leavesley DI, Kashyap AS, Croll T, Sivaramakrishnan M, Shokoohmand A, Hollier BG, Upton Z. Vitronectin: master controller or micromanager? IUBMB Life. 2013;65:807–18. https://doi.org/10.1002/iub.1203.

    Article  CAS  PubMed  Google Scholar 

  • Lim BL, Reid KB, Ghebrehiwet B, Peerschke EI, Leigh LA, Preissner KT. The binding protein for globular heads of complement C1q, gC1qR. Functional expression and characterization as a novel vitronectin binding factor. J Biol Chem. 1996;271:26739–44.

    Article  CAS  PubMed  Google Scholar 

  • Podack ER, Preissner KT, Müller-Eberhard HJ. Inhibition of C9 polymerization within the SC5b-9 complex of complement by S-protein. Acta Pathol Microbiol Immunol Scand Suppl. 1984;284:89–96.

    CAS  PubMed  Google Scholar 

  • Preissner KT, Wassmuth R, Müller-Berghaus G. Physicochemical characterization of human S-protein and its function in the blood coagulation system. Biochem J. 1985;231:349–55.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Preissner KT. Structure and biological role of vitronectin. Annu Rev Cell Biol. 1991;7:275–310.

    Article  CAS  PubMed  Google Scholar 

  • Preissner KT, Chhatwal GS. Extracellular matrix and host cell surfaces: potential sites of pathogen interaction. In: Cossart P, Boquet P, Normark S, Rappuoli R, editors. Cellular microbiology. 2nd ed. Washington, DC: ASM Press; 2005. p. 88–105.

    Google Scholar 

  • Preissner KT, Reuning U. Vitronectin in vascular context: facets of a multitalented matricellular protein. Semin Thromb Hemost. 2011;37:408–24. https://doi.org/10.1055/s-0031-1276590.

    Article  CAS  PubMed  Google Scholar 

  • Schmidt CQ, Lambris JD, Ricklin D. Protection of host cells by complement regulators. Immunol Rev. 2016;274:152–71. https://doi.org/10.1111/imr.12475.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Seiffert D. Constitutive and regulated expression of vitronectin. Histol Histopathol. 1997;12:787–97.

    CAS  PubMed  Google Scholar 

  • Seiffert D, Keeton M, Eguchi Y, Sawdey M, Loskutoff DJ. Detection of vitronectin mRNA in tissues and cells of the mouse. Proc Natl Acad Sci USA. 1991;88:9402–6.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Seiffert D, Loskutoff DJ. Evidence that type 1 plasminogen activator inhibitor binds to the somatomedin B domain of vitronectin. J Biol Chem. 1991;266:2824–30.

    CAS  PubMed  Google Scholar 

  • Tomasini BR, Mosher DF. Vitronectin. Prog Hemost Thromb. 1991;10:269–305.

    CAS  PubMed  Google Scholar 

  • Upton Z, Cuttle L, Noble A, Kempf M, Topping G, Malda J, Xie Y, Mill J, Harkin DG, Kravchuk O, Leavesley DI, Kimble RM. Vitronectin: growth factor complexes hold potential as a wound therapy approach. J Invest Dermatol. 2008;128:1535–44. https://doi.org/10.1038/sj.jid.5701148.

    Article  CAS  PubMed  Google Scholar 

  • Yi M, Sakai T, Fässler R, Ruoslahti E. Antiangiogenic proteins require plasma fibronectin or vitronectin for in vivo activity. Proc Natl Acad Sci USA. 2003;100:11435–8. https://doi.org/10.1073/pnas.1635112100.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Zheng X, Saunders TL, Camper SA, Samuelson LC, Ginsburg D. Vitronectin is not essential for normal mammalian development and fertility. Proc Natl Acad Sci USA. 1995;92:12426–30.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Biochemistry, Medical School, Justus-Liebig-University, Friedrichstrsse 24, 35392, Giessen, Germany

    Klaus T. Preissner

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  1. Klaus T. Preissner
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Correspondence to Klaus T. Preissner .

Editor information

Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Preissner, K.T. (2018). Vitronectin. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101907

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