Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi


  • Klaus T. PreissnerEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101907


Historical Background

VN was first described as a “serum spreading factor” to promote the attachment and spreading of cells to various surfaces, and it is this property of plasma/serum that enables mammalian cells to adhere to culture dishes and propagate (Leavesley et al. 2013). Unrelated investigations in cellular movement and epiboly as well as in innate immunity lead to the term “epibolin” or the discovery of VN as the complement inhibitor “S-protein,” respectively, whereby the identity of both factors was uncovered 30 years ago by the author.

VN Gene and Expression of the VN Protein

Gene Structure

The human VN gene (about 3.5 kb) is localized on chromosome 17 (centromeric region 17q11); the murine VN gene is found on chromosome 10. Both VN genes consist of eight exons and seven introns, resulting in 1.7 kb transcripts without indication for alternative splicing (Jenne and...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of BiochemistryMedical School, Justus-Liebig-UniversityGiessenGermany