Synonyms
Cardiac troponin C: Tncc; Tnnc1; Troponin C, cardiac; Troponin C, cardiac/slow skeletal
Cardiac troponin I: cTnI, the inhibitory subunit of troponin (Tn); Tn1; TNNC1; Tnni3; Troponin I, cardiac
Cardiac troponin T: cTnT, the tropomyosin-binding subunit of troponin (Tn); Ctt; CTTG; RATCTTG; Tnnt2; TnT; Troponin T, cardiac; Troponin T2; Troponin T2, cardiac
Historical Background
The modern molecular understanding of muscle contraction took shape in the 1950s and 1960s. The sliding filament model was proposed in 1954, and it was known that muscle contraction was driven by myosin ATPase in the presence of actin. In the early 1960s, it was suspected, though not widely accepted, that muscle contraction is triggered by calcium. The idea was controversial, because while native preparations of actomyosin could be induced to relax by calcium-chelating agents, highly purified and reconstituted actomyosin did not display this behavior. In 1963, Ebashi demonstrated that the calcium...
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Mahmud, Z., Hwang, P.M. (2018). Cardiac Troponin Complex: Cardiac Troponin C (TNNC1), Cardiac Troponin I (TNNI3), and Cardiac Troponin T (TNNT2). In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101901
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