Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Cardiac Troponin Complex: Cardiac Troponin C (TNNC1), Cardiac Troponin I (TNNI3), and Cardiac Troponin T (TNNT2)

  • Zabed Mahmud
  • Peter M. HwangEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101901


Historical Background

The modern molecular understanding of muscle contraction took shape in the 1950s and 1960s. The sliding filament model was proposed in 1954, and it was known that muscle contraction was driven by myosin ATPase in the presence of actin. In the early 1960s, it was suspected, though not widely accepted, that muscle contraction is triggered by calcium. The idea was controversial, because while native preparations of actomyosin could be induced to relax by calcium-chelating agents, highly purified and reconstituted actomyosin did not display this behavior. In 1963, Ebashi demonstrated that...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of BiochemistryUniversity of AlbertaEdmontonCanada
  2. 2.Department of MedicineUniversity of AlbertaEdmontonCanada