Glioma-Associated Oncogene 1 (GLI1)
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Historical Background and GLI Family Tree
Vogelstein and colleagues discovered GLI1 (Kinzler et al. 1987) as an amplified gene in a human glioma cell line derived from a 46-year-old male patient. The investigation utilized a denaturation-renaturation gel technique to identify DNA regions that are extensively amplified which led to the observation of a greater than 50-fold amplification of a novel gene, originally named GLI (Kinzler et al. 1987). Cloning and sequencing of the GLI gene showed that its predicted protein product contained five C2H2 zinc fingers and was structurally related to the Kruppel gene family (Kinzler et al. 1988; Ruppert et al. 1988). After the cloning of additional GLI-related genes, GLI was renamed GLI1 (Ruppert et al. 1988; Ruiz i Altaba 1999).
In vertebrates, the GLI gene family consists of GLI1, GLI2, and GLI3. The encoded GLI proteins have regions of high homology, but each...
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