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Encyclopedia of Signaling Molecules pp 4245–4253Cite as

Proteinase-Activated Receptors (PARs)

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Synonyms

PAR1:CF2R; Coagulation factor II thrombin receptor; Coagulation factor II (thrombin) receptor; HTR; Proteinase-activated receptor 1; PAR1; PAR-1; Thrombin receptor; TR

PAR2:F2RL1; F2R-like trypsin receptor 1; GPR11; Proteinase-activated receptor 2; PAR2; PAR-2

PAR3:Coagulation factor II thrombin receptor-like 2; Coagulation factor II (thrombin) receptor-like 2; F2RL2; Proteinase-activated receptor 3; PAR3; PAR-3; Thrombin receptor-like 2

PAR4:Coagulation factor II (thrombin) receptor-like 3; Coagulation factor II receptor-like 3; F2RL3; F2R-like thrombin/trypsin receptor 3; PAR4; PAR-4; Proteinase-activated receptor 4; Thrombin receptor-like 3

Historical Background

Since about 50 years, serine proteinases like chymotrypsin and pepsin have been known to cause hormone-like effects in target tissues. In addition, in the 1970, thrombin and trypsin have been demonstrated to stimulate mitogenesis by acting at the cell surface. However, the mechanisms responsible for the growth...

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Author information

Authors and Affiliations

  1. Department of General, Visceral and Vascular Surgery, Jena University Hospital, Am Klinikum 1, D-07747, Jena, Germany

    Roland Kaufmann & Utz Settmacher

  2. University of Lübeck, Lübeck, Germany

    Hendrik Ungefroren

Authors
  1. Roland Kaufmann
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  2. Utz Settmacher
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  3. Hendrik Ungefroren
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Corresponding author

Correspondence to Roland Kaufmann .

Editor information

Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Kaufmann, R., Settmacher, U., Ungefroren, H. (2018). Proteinase-Activated Receptors (PARs). In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101885

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