Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Proteinase-Activated Receptors (PARs)

  • Roland KaufmannEmail author
  • Utz Settmacher
  • Hendrik Ungefroren
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101885


Historical Background

Since about 50 years, serine proteinases like chymotrypsin and pepsin have been known to cause hormone-like effects in target tissues. In addition, in the 1970, thrombin and trypsin have been demonstrated to stimulate mitogenesis by acting at the cell surface. However, the mechanisms...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Roland Kaufmann
    • 1
    Email author
  • Utz Settmacher
    • 1
  • Hendrik Ungefroren
    • 2
  1. 1.Department of General, Visceral and Vascular SurgeryJena University HospitalJenaGermany
  2. 2.University of LübeckLübeckGermany