Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi


  • Romain GuinamardEmail author
  • Christophe Simard
  • Laurent Sallé
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101882


Historical Background

Transient receptor potential, subfamily M(melastatin-related), member 4 (TRPM4) gene encodes a channel protein responsible for a Ca2+-activated nonselective cationic (NSCCa) current. Electrophysiological signatures of such currents are known since the beginning of patch clamp single-channel recordings. They were observed in a wide variety of tissues in the 1980s to 2000s, including epithelia, secretory tissues, or excitable cells (neurons and myocytes) (see Guinamard et al. 2011for review). However, these currents remained orphaned until the cloning of the TRP gene family at the end of the 1990s. Among these, TRPM1 (melastatin) has been cloned in 1998 and opened the way for the new subfamily TRPM which is composed of eight members (1–8). Based on homology sequence screening of a cDNA library, Xu et al. identified a first sequence of the TRPM4 gene in...

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© Springer International Publishing AG 2018

Authors and Affiliations

  • Romain Guinamard
    • 1
    Email author
  • Christophe Simard
    • 1
  • Laurent Sallé
    • 1
  1. 1.Signalisation, électrophysiologie et imagerie des lésions d’ischémie-reperfusion myocardiqueNormandie Univ, UNICAENCaenFrance