Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

TRPV3 (Transient Receptor Potential Channel Subfamily V Member 3)

  • Jialie Luo
  • Hongzhen HuEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101877


Historical Background

TRPV3, a member of the subfamily V of transient receptor potential (TRP) channel family, was first identified as a temperature-sensitive nonselective cation channel by three independent research groups (Smith et al. 2002; Xu et al. 2002; Peier et al. 2002). TRPV3 channels have a large unitary conductance of about 150–200 pS and share 43% sequence homology with TRPV1, the capsaicin receptor. Like many other TRP channels, TRPV3 is a tetramer, and each subunit is composed of six transmembrane (TM) domains. The putative pore loop is located between TM5 and TM6 (Xu et al. 2002). TRPV3 is preferentially permeable to Ca2+, and its permeability ratio of Ca2+/Na+ is estimated to be around 10–15. Functional TRPV3 channel is present in both neuronal and non-neuronal tissues with a prominent expression in the skin, where it plays important roles in skin physiology and disease (Smith et al. 2002).

Activation and...

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© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.The Center for the Study of Itch, Department of AnesthesiologyWashington University in Saint LouisSaint LouisUSA