Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

SLC24A Family (K+-Dependent Na+-Ca2+ Exchanger, NCKX)

  • Ali H. Jalloul
  • Robert T. Szerencsei
  • Tatiana P. Rogasevskaia
  • Paul P. M. SchnetkampEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101860


Historical Background

Tightly controlled changes in cytosolic free Ca2+ concentration are widely involved in cell signaling in most tissues of our body. Free Ca2+ concentration is increased through the activation of a wide range of surface or intracellular Ca2+ channels and is returned to resting values through the action of ATP-driven Ca2+ pumps located in the plasma membrane and endoplasmic reticulum as well as Na+/Ca2+ exchangers located on the plasma membrane. By the mid 1980s, it had been established that the surface membrane of the outer segments of retinal rod photoreceptors (ROS) contained a potent Na+-Ca2+ exchange mechanism (Schnetkamp 1980; Yau and Nakatani 1984), and, in 1988, the Na+-Ca2+ exchanger protein was purified from bovine ROS as a 220 kDa glycoprotein (Cook and Kaupp 1988). In...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Ali H. Jalloul
    • 1
  • Robert T. Szerencsei
    • 1
  • Tatiana P. Rogasevskaia
    • 1
    • 2
  • Paul P. M. Schnetkamp
    • 1
    Email author
  1. 1.Department of Physiology and Pharmacology, Hotchkiss Brain Institute, Cumming School of MedicineUniversity of CalgaryCalgaryCanada
  2. 2.Department of BiologyMount Royal UniversityCalgaryCanada