Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi


  • Paridhy Vanniya S.
  • Sireesh Dornadula
  • Dhamodharan Umapathy
  • Ponjayanthi Balashanmugam
  • Srikumari Srisailapthy C. R.
  • Ramkumar Kunka MohanramEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101855


Historical Background

The substrate adaptor protein Keap1 has emerged as a key sensor for oxidative stress and electrophilic molecules. Initially, the Keap1 gene KIAA0132 was mapped to chromosome 19 (Nagase et al. 1995) and later identified by yeast-two hybrid screening as an interacting partner of Nrf2 (transcription factor). Keap1 was named so due to its homology to the actin binding egg-chamber regulatory protein “Kelch” in Drosophila. It was found to be a major negative regulator of Nrf2-mediated transactivation of ARE-dependent proteins (Itoh et al. 1999). Subsequent research facilitated understanding the role of Keap1 in Nrf2 ubiquitination, proteasomal degradation, and its dysregulation. Mice with Keap1 null mutation presented with postnatal lethality due to severe hyperkeratotic constrictions in the esophagus and forestomach; at the cellular level, absence of Keap1 resulted...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Paridhy Vanniya S.
    • 1
  • Sireesh Dornadula
    • 2
  • Dhamodharan Umapathy
    • 2
  • Ponjayanthi Balashanmugam
    • 2
  • Srikumari Srisailapthy C. R.
    • 1
  • Ramkumar Kunka Mohanram
    • 2
    Email author
  1. 1.Department of Genetics, Dr. ALM PG Institute of Basic Medical ScienceUniversity of MadrasChennaiIndia
  2. 2.SRM Research InstituteSRM UniversityKattankulathur, ChennaiIndia