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Encyclopedia of Signaling Molecules pp 3325–3337Cite as

Na+/HCO3− Cotransporter NBCn1

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Synonyms

NBC2; NBC3; NBCn1; SLC4A7

Historical Background

NBCn1 is an electroneutral Na+/HCO3− cotransporter encoded by SLC4A7 gene, a member of the bicarbonate transporter family of solute carrier 4 (SLC4). In total, this family contains ten members: (1) three electroneutral anion exchangers AE1 (SLC4A1), AE2 (SLC4A2), and AE3 (SLC4A3); (2) five Na+-coupled HCO3− transporters (NCBTs), including two electrogenic Na+/HCO3− cotransporters NBCe1 (SLC4A4), NBCe2 (SLC4A5), two electroneutral Na+/HCO3− cotransporters NBCn1 and NBCn2 (SLC4A10), and an electroneutral Na+-driven Cl−/HCO3− exchanger NDCBE (SLC4A8); (3) two less well-characterized members SLC4A9 and SLC4A11.

The association between the transport of Na+ and HCO3− was reported in 1970s in epithelial cells from different systems, such as proximal tubules (Burg and Green 1977) and jejunum (Turnberg et al. 1970; Podesta and Mettrick 1977). In 1983, Boron and Boulpaep clearly conceptualized for the first time Na+/HCO3−cotransporter...

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Authors and Affiliations

  1. Department of Biophysics and Molecular Physiology, Key Laboratory of Molecular Biophysics of Ministry of Education, Huazhong University of Science and Technology School of Life Science and Technology, Wuhan, 430074, China

    Ying Liu, Xiao-Yu Wang, Zhang-Dong Xie & Li-Ming Chen

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  1. Ying Liu
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  2. Xiao-Yu Wang
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  3. Zhang-Dong Xie
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  4. Li-Ming Chen
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Correspondence to Li-Ming Chen .

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Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Liu, Y., Wang, XY., Xie, ZD., Chen, LM. (2018). Na+/HCO3− Cotransporter NBCn1. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101854

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