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The RASSF (Ras Association Domain Family) protein family is a group of ten proteins which has been expanding and gaining interest due to their roles in human pathology. The family is named due to the presence of an RA (Ras-association) domain, the location of which is used to classify the RASSF proteins as C- or N-terminal RASSF proteins (Fig. 1). Interest in the family is fueled by the tumor-suppressive roles displayed by several RASSF members. RASSF7 was arguably the first of the family to be described as HRC-1 (Weitzel et al. 1992); however, it has only recently been renamed to join the ranks of the RASSF family. Therefore, NORE1 (RASSF5) is often considered the founding member following its identification as a Ras effector (Vavvas et al. 1998), joined shortly afterwards by RASSF1, which was originally discovered in the hunt for a lung cancer tumor suppressor on the short arm of chromosome 3 (Dammann et al. 2000...
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