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TAK1

  • Reference work entry
  • First Online:
Encyclopedia of Signaling Molecules

  • 134 Accesses

Synonyms

MAP3K7; MEKK7; Mitogen-activated protein kinase kinase kinase 7; TGF-beta activated kinase 1; Transforming growth factor-beta-activated kinase 1

Historical Background

Matsumoto and his colleagues discovered the kinase transforming growth factor β-activated kinase 1 (TAK1) as a new member of MAP triple kinase (MAPKKK) in 1995 using yeast complementation screening (Yamaguchi et al. 1995). TAK1 is ubiquitously expressed in all tissues and four splicing variants have been reported in human. Structurally, TAK1 has an N-terminal kinase domain and a C-terminal regulatory domain. MAPKKK is a serine/threonine-specific protein kinase involved in cellular signal transduction, where MAPKKKs phosphorylate downstream dual-specificity protein kinase MAPKKs, which in turn phosphorylates the MAPKs to regulate a variety of biological events such as cell proliferation, migration, survival, and differentiation. TAK1 has been shown to activate MAPKK3/6 and MAPKK4/7, leading to downstream...

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References

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Authors and Affiliations

  1. Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Jordan Hall 7315, Charlottesville, VA, 22908, USA

    Sho Morioka

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  1. Sho Morioka
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Correspondence to Sho Morioka .

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Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Morioka, S. (2018). TAK1. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101848

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