Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

SH2B Adapter Protein 3 (SH2B3)

  • Béatrice L. CharreauEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101847


 Lnk;  SH2B3

Historical Background

SH2B3 belongs to the Src homology 2B (SH2B) adapter protein family described in the late 1990s. The SH2B family contains three members (SH2B1, SH2B2, and SH2B3) in mammals. SH2B1, SH2B2, and SH2B3 were originally named as SH2-B [also known as SH2 domain-containing signaling mediator (PSM)], adapter protein with PH and SH2 domains (APS) and Lnk, respectively. The SH2B family is evolutionarily conserved from insects through humans. Unlike mammals, insects have only one SH2B gene (also called Lnk or dSH2B). SH2B3 cDNA was initially cloned and characterized in rat and then in mice in 1997 by Takaki and colleagues who described the first transgenic mice for Lnk/SH2B3 and established SH2B3 as a regulator of signaling in T and B cells (Takaki et al. 1997). Subsequent studies revealed a more widespread role for SH2B3 in myeloid development and hematopoiesis. The deduced amino acid sequences of mouse and rat SH2B3 share 96% identity and 98%...

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This work was realized in the context of the IHU-Cesti, LabEx IGO, and LabEx Transplantex projects which received French government financial support managed by the National Research Agency (ANR) via the “Investment Into The Future” programs ANR-10-IBHU-005, ANR-11-LABX-0016-01, and ANR-11-LABX-0070. The IHU-Cesti project is also supported by Nantes Metropole and the Pays de la Loire Region. This study is also supported by the Region Pays de la Loire, the “Fondation Centaure” (RTRS) which supports a French transplantation research network and by The Agence de la Biomédecine. I apologize that all references could not be cited due to space restrictions.


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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Centre de Recherche en Transplantation et Immunologie UMR1064, INSERMUniversité de NantesNantesFrance
  2. 2.Institut de Transplantation Urologie Néphrologie (ITUN)CHU NantesNantesFrance