Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Torsin 1A Interacting Protein 1

  • Joana B. Serrano
  • Filipa Martins
  • Ana M. Marafona
  • Odete A. B. da Cruz e Silva
  • Sandra Rebelo
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101846

Synonyms

Historical Background

Lamina associated polypeptide 1 (LAP1) was identified in 1988 as an integral inner nuclear membrane (INM) protein associated with lamins. LAP1 family members were identified using a monoclonal antibody against rat liver nuclear envelope (NE) extracts (Senior and Gerace 1988). This antibody recognized three polypeptides with apparent molecular weights of 75 KDa, 68 KDa, and 55 KDa in rat liver NEs that were subsequently termed LAP1A, LAP1B, and LAP1C, respectively. The evidence that LAP1 was connected to nuclear lamina was achieved by biochemical extraction experiments, and subsequent in vitro experiments demonstrated that LAP1A and LAP1B bind directly to lamins A, C, and B1 and most likely indirectly to chromosomes (Foisner and Gerace 1993). Further co-immunoprecipitation studies demonstrated that LAP1A/LAP1C co-immunoprecipitated...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Joana B. Serrano
    • 1
  • Filipa Martins
    • 1
  • Ana M. Marafona
    • 1
  • Odete A. B. da Cruz e Silva
    • 1
  • Sandra Rebelo
    • 1
  1. 1.Neuroscience and Signaling Laboratory, Department of Medical Sciences, Institute of Biomedicine-iBiMEDUniversity of AveiroAveiroPortugal