Stromal Interaction Molecule
STIM1 is a key protein in initiation of calcium flux. STIM1 senses and reacts to changes in the levels of stored calcium ions (Ca+2) in a cell. Cells keep tight control on many important intracellular calcium-dependent processes by controlling the availability of free Ca+2, maintaining low levels of free Ca+2 in the cytosol relative to extracellular and stored intracellular Ca+2 levels. In calcium flux, intracellular release of stored Ca+2 ions, primarily stored in the endoplasmic reticulum (ER) of non-muscle cells or in the sarcoplasmic reticulum in muscle cells, can initiate specific calcium-dependent activities in the cell, such as enzyme activation. The release of stored Ca+2 into the cytosol then triggers an influx of extracellular Ca+2 through cell membrane channels to amplify the calcium-dependent activities. This is referred to as SOCE (storage-operated calcium entry). The extracellular Ca+2ions enter through CRAC channels...
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