Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

SLC28 and SLC29

  • Sylvia Y. M. Yao
  • James D. YoungEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101838


 SLC28: Solute carrier family 28; Concentrative nucleoside transporter; CNT1; CNT2; CNT3

 SLC29: Solute carrier family 29; Equilibrative nucleoside transporter; ENT1; ENT2; ENT3; ENT4/PMAT

Historical Background

Pyrimidine and purine nucleosides and their derivatives play critical roles in physiology and have diverse pharmacological applications (Young et al. 2013). As central “salvage” metabolites, they can be converted to nucleotides, which serve as the energy-rich currency of intermediary metabolism and are the precursors of nucleic acids. The nucleoside adenosine is also a key signaling molecule that modulates multiple physiological processes through interaction with cell-surface P1 purinergic receptors. Clinically, nucleoside and nucleobase drugs are widely used to treat cancer and viral infections.

Nucleosides and their derivatives are generally hydrophilic in nature, and their availabilities within cells and in the extracellular environment are primarily determined by...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.University of AlbertaEdmontonCanada