Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Tyrosine-Protein Phosphatase Nonreceptor Type 11 (PTPN11)

  • Takenori Kotani
  • Yoji Murata
  • Yasuyuki Saito
  • Takashi Matozaki
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101832

Synonyms

Historical Background

Src homology 2-containing protein tyrosine phosphatase (SHP2, also known as PTPN11) is a member of the non-receptor-type protein tyrosine phosphatase (PTP) family and is encoded by PTPN11gene. In the early 1990s, this PTP was identified on the basis of its sequence similarity to the catalytic domain of known PTPs. PTPs dephosphorylate tyrosine-phosphorylated proteins, which generally promote cellular events such as cell growth, differentiation, migration, adhesion, and apoptosis. Therefore, PTPs are considered to be negative regulators in intracellular signal transductions. However, biochemical and genetic analyses in 1990s showed that SHP2 promotes...

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References

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Division of Molecular and Cellular Signaling, Department of Biochemistry and Molecular BiologyKobe University Graduate School of MedicineKobeJapan