Endothelial plasminogen activator inhibitor; Mr1; Nexin, plasminogen activator inhibitor type 1; PAI; PAI1; PAI-1; Planh; PLANH1; Planh1; Plasminogen activator inhibitor 1; Plasminogen activator inhibitor type-1 (PAI-1); Plasminogen activator inhibitor-1; Serine (or cysteine) peptidase inhibitor, clade E, member 1
The temporal and spatial control of a complex extracellular proteolytic cascade regulates the fundamental processes of tissue remodeling, inflammation, thrombosis, and wound repair. Growth factor and cytokine-induced release of two plasminogen activators (PAs; urokinase-type PA, uPA; tissue-type PA, tPA) converts plasminogen to plasmin, a trypsin-like protease that in turn activates several matrix metalloproteinases to implement extracellular matrix (ECM) restructuring (Van den Steen et al. 2001). The broad substrate specificity of plasmin requires strict control of its activity which is mainly accomplished by several plasminogen...
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