Type I Interferons
Investigating the general phenomenon of “viral interference,” where the prior infection by one nonlethal virus might interfere with a subsequent infection of cells by a second virus, Isaacs, Lindenmann, and colleagues published a series of articles in 1957 showing that an inactivated influenza virus, reacting with cells of chick allantoic membrane, can elicit the secretion of a proteinaceous substance, “the interferon,” into the medium that can, when incubated with fresh cells, confer protection against viral infection on these cells (Isaacs and Lindenmann 1957). The next 20 years saw explorations of what types of cells could secrete “interferon,” what substances – viruses or chemical – could induce interferons and initial explorations of biological and therapeutic function. Heterogeneity of “interferon” was initially...
- Kotenko SV, Durbin, JE. Contribution of Type III interferons to antiviral immunity: Location, location, location. J Biol Chem. 2017 (epub ahead of publication) https://doi.org/10.1074/jbc.R117.777102
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