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Regulator of G-Protein Signaling 1 (RGS1)

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Encyclopedia of Signaling Molecules

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Synonyms

1R20; B cell activation protein BL34; BL34; Early response protein 1R20; IER1; Immediate-early response 1, B cell specific; IR20; Regulator of G-protein signaling 1; RGS1

Historical Background

G-protein-coupled receptors (GPCRs) are cell-surface transmembrane proteins that mediate the effects of a broad spectrum of biological signals. GPCRs signal through heterotrimeric G-proteins that are localized on the inner surface of the plasma membrane and that consist of three subunits: α, β, and γ subunits. Four families of Gα subunits can be distinguished based on their function and amino acid homology, and they are termed: Gαs, Gαi, Gαq, and Gα12 (Gilman 1987). Regulator of G-protein signaling (RGS) family proteins are important effectors that mediate the strength and duration of GPCR and act as negative regulators of the GPCR signaling pathways. RGS proteins function as GTPase-activating proteins (GAPs) that accelerate the GTPase activity of Gαsubunits, driving G-protein into its...

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Authors and Affiliations

  1. Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens, GA, USA

    Josephine Bou Dagher & Jae-Kyung Lee

Authors
  1. Josephine Bou Dagher
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  2. Jae-Kyung Lee
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Correspondence to Jae-Kyung Lee .

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Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Dagher, J.B., Lee, JK. (2018). Regulator of G-Protein Signaling 1 (RGS1). In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101824

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