SARM1 (Sterile Alpha and TIR Motif-Containing Protein 1), Fig. 4From: SARM1 (Sterile Alpha and TIR Motif-Containing Protein 1)SARM1 mediates axonal degeneration. Axonal injury induced by physical or chemical damage triggers SARM1 activation via loss of NMNAT2 or other unknown factor subsequently activates the MKK-JNK signaling and then causes cytoskeleton breakdownBack to chapter page