SARM1 (Sterile Alpha and TIR Motif-Containing Protein 1), Fig. 3
From: SARM1 (Sterile Alpha and TIR Motif-Containing Protein 1)
SARM1 regulates neuronal development in distinct species. (a) TIR-1-MAPK signaling regulates asymmetric odorant receptor expression that subsequently determines the neuronal cell fate in C. elegans. Calcium and CaMKII act upstream of this process. (b) Toll-6, one of Drosophila TLRs, regulates FoxO translocation into the nucleus to suppress Pav-KLP expression. It consequently increases microtubule dynamic, promotes NMJ growth, and enhances presynaptic plasticity. The SARM1-JNK signaling acts downstream of Toll-6 and upstream of FoxO. (c) SARM1 receives signal from syndecan-2 or other factor and acts through the ASK1-MKK4/7-JNK cascade to increase microtubule stability and regulate dendritic arboration in mammalian