Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

S6K (S6 Kinase)

  • Isadora Carolina Betim Pavan
  • Fernando Riback Silva
  • Ana Paula Morelli
  • Fernando Moreira SimabucoEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101816


Historical Background

The ribosomal S6 protein kinases (S6Ks) represent a superfamily of proteins which were originally discovered to phosphorylate ribosomal protein S6. Proteins known as p90 ribosomal S6 kinases (RSKs) have been first identified as able to phosphorylate ribosomal protein S6 (Jones et al. 1988). A short time later, S6K1 protein was discovered gaining a major role in S6 phosphorylation in somatic cells, while RSKs gained less significance in this process (Banerjee et al. 1990). It is important to note that RSKs and S6Ks belong to different subfamilies of serine/threonine kinases...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Isadora Carolina Betim Pavan
    • 1
  • Fernando Riback Silva
    • 1
  • Ana Paula Morelli
    • 1
  • Fernando Moreira Simabuco
    • 1
    Email author
  1. 1.Laboratory of Metabolic Disorders, School of Applied SciencesUniversity of CampinasLimeiraBrazil