Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Matrix Metalloproteinases

  • Snehasikta SwarnakarEmail author
  • Sayantan Jana
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101814


Historical Background

It traces back to the discovery of a protease from metamorphosed tadpole about 60 years ago by Jerome Gross, which eventually opened a new field of metalloprotease biochemistry (Gross and Lapiere 1962). The protease discovered then was an interstitial collagenase, also known as matrix metalloproteinase-1 (MMP-1) that involved in extracellular matrix (ECM) degradation. The complete protease repertoire of human accounting ∼2% of whole genome holds a great treasure of information on human health and diseases. All proteases are classified into five classes, namely, serine, threonine, cysteine, aspartic, and metalloproteinase proteases. Metalloprotease encompasses metzincin superfamily, which is further divided into five groups, e.g., astacin, serralysin, adamlysin, pappalysin, and matrixins (Lopez-Otin and Matrisian 2007). MMPs (or matrixins) are calcium-dependent zinc containing endopeptidases and members of metzincin...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Cancer Biology and Inflammatory Disorder DivisionCSIR-Indian Institute of Chemical BiologyKolkataIndia