Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi


  • Francois Alhenc-GelasEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101810


Historical Background

Discovered as a hypotensive agent present in urine (Abelous and Bardier 1909; Frey and Kraut 1928). Hypotensive effect later assigned to release of vasodilator peptides, kinins, through enzymatic hydrolysis of protein precursors, kininogens (discovery of the enzymatic activity of kallikrein, Werle 1937).

First cloning of KLK1 gene in the mouse and description of the kallikrein gene family, followed by the rat and human kallikrein gene families, all subsequently expanded (Mason et al. 1983, Lundwall et al. 2006).

Inactivation of the KLK1 gene in the mouse (Meneton et al. 2001).

Description of the genetic determinism of urinary K1 activity in man and elucidation of its molecular basis (Zinner et al. 1976; Slim et al. 2002).

Kallikrein-K1 or tissue kallikrein should not be confounded with another enzyme called “plasma kallikrein”...

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© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.INSERM U1138, Centre de Recherche des CordeliersParis-Descartes Universty, Pierre and Marie Curie UniversityParisFrance