Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Heat Shock Protein (HSP)

  • Betul KarademirEmail author
  • Gulce Sari-Kaplan
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101809


There are synonyms of each HSP members in mammals:  DNAJ: HSP40;  HSPA: HSP70;  HSPB: small HSP families;  Human chaperonin families: HSP60 and CCT;  HSPC: HSP90;  HSPH: HSP110 (Kampinga et al. 2009).

The cellular and species-specific isoforms are given in each part of the text.

Historical Background

Heat shock proteins (HSPs) were first described by Ritossa (1962) in Drosophila (Drosophila busckii and Drosophila melanogaster) in response to temperature, and the active genes coding HSPs are called puffs. Ritossa (1962) also showed increased expression of HSPs following 2,4-Dinitrophenol (DNP) treatment instead of temperature (Ritossa 1962). Later, Koninkx (1976) decided to analyze all inducing conditions of HSPs in Drosophila, so he studied several stress conditions on different tissues and finally reported that puffs could be detected under different stress conditions not only temperature changes. Koninkx (1976) also used the term “heat shock proteins” for puff patterns...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of Medical BiochemistryMarmara University School of MedicineMaltepe, IstanbulTurkey