Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi


  • Hidenori ShirahaEmail author
  • Shigeru Horiguchi
  • Hiroyuki Okada
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101799


Historical Background

In studies on murine polyoma and leukemia viruses, mammalian core-binding factors (CBFs) were identified as proteins regulating viral replication (Boral et al. 1989; Speck and Terryl 1995). Investigating the regulatory mechanism of viral replication led to the identification of the polyomavirus enhancer-binding protein 2 (PEBP2), also known as core-binding factor-β (CBF-β) (Katinka et al. 1980; Tanaka et al. 1982). Further study revealed that PEBP2/CBFB was composed of dimers of a DNA-binding subunit (CBF-α) and a non-DNA-binding subunit (CBF-β). Gene cloning investigations discovered that CBF-α was encoded by RUNX genes (RUNX1/CBFA2/PEBPA2B, RUNX2/CBFA1/PEBPA2A, and RUNX3/CBFA3/PEBPA2C...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Hidenori Shiraha
    • 1
    Email author
  • Shigeru Horiguchi
    • 1
  • Hiroyuki Okada
    • 1
  1. 1.Department of Gastroenterology and HepatologyOkayama University Faculty of MedicineOkayamaJapan